Results 151 to 160 of about 5,296,053 (293)

Primary care doctors in acute call-outs to severe trauma incidents in Norway - variations by rural-urban settings and time factors. [PDF]

BMC Emerg Med
Myklevoll KR, Zakariassen E, Morken T, Baste V, Blinkenberg J, Bondevik GT.   +5 more
europepmc   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Temporalities of oxytocin for labour augmentation: a mixed-methods study of time factors shaping labour practices in a busy maternity unit in Tanzania. [PDF]

BMC Pregnancy Childbirth
Kujabi ML, Maembe L, Nkungu D, Maaløe N, D'mello BS, van Roosmalen J, van den Akker T, Konradsen F, Hussein K, Pallangyo E, Skovdal M, Sørensen JB.   +11 more
europepmc   +1 more source

Heparin Tolerance Determinating Factors Evaluated by the Heparin Thrombin Clotting Time [PDF]

, 1977
Per Kragh Andersen, H. C. Godal
openalex   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

The impact of the time factors on the exercise-based cardiac rehabilitation outcomes of the patients with acute myocardial infarction after percutaneous coronary intervention: a systematic review and meta-analysis. [PDF]

BMC Cardiovasc Disord
Zhang P, Niu C, Zhang L, Lai H, Liu B, Lv D, Zhuang R, Liu Y, Xiao D, Ma L, Li M.   +10 more
europepmc   +1 more source

Contributions of Genetic and Environmental Factors to Time Trends in Milk Yield and Percent Fat in Advanced Registry Holstein Cows of Hokkaido, japan, during the 1948-1958 Period

, 1961
Takeo ABE
openalex   +2 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Environmental Factors Underlying the Occurrence of Cancer in a Volcanic Country : On the Correlation between the Flourine Content in Rice and Death Rates from Gastric Cancer According to Time and Geography in Japan

, 1967
Tomonori Okamura, Takeshi Matsuhisa
openalex   +2 more sources