Results 121 to 130 of about 2,865,323 (310)

Performance Bound Analysis of Analog Circuits in Frequency- and Time-Domain Considering Process Variations [PDF]

, 2013
In this article, we propose a new performance bound analysis of analog circuits considering process variations. We model the variations of component values as intervals measured from tested chips and manufacture processes.
ADOLFO ADAIR PALMA RODRIGUEZ, ESTEBAN TLELO CUAUTLE   +1 more
core  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Energy dissipation and time-frequency analysis of characteristics induced by vortex breakdown in an axial flow pump [PDF]

Vortex breakdown in a pump sump is a complex and negative factor for the pump. Different from my previous study that focused mainly on the development process of vortex and its damage to the pump, this paper is from a new perspective that studies the ...
Liu, Chao, Jin, Yan, Presas Batlló, Alexandre, Tang, Fangping, Wang, Zhengwei, Song, Xijie   +5 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A Frequency-selective Filter for Short-Length Time Series [PDF]

An effective and easy-to-implement frequency filter is designed by convolving a Hamming window with the ideal rectangular filter response function. Three other filters, Hodrick-Prescott, Baxter-King, and Christiano-Fitzgerald, are critically reviewed ...
Alain Noullez, Alessandra Iacobucci
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Diagnosis of industrial gearboxes condition by vibration and time-frequency, scale-frequency, frequency-frequency analysis

Metalurgija, 2012
In the article methods of vibroacoustic diagnostics of high-power toothed gears are described. It is shown below, that properly registered and processed acoustic signal or vibration signal may serve as an explicitly interpreted source of diagnostic ...
P. Czech
doaj  

New method for detecting site liquefaction trigger time based on strong motion records

Yantu gongcheng xuebao
The mechanical properties of soils undergo significant changes before and after liquefaction during an earthquake, which consequently lead to a qualitative shift in surface and structural damage mechanisms.
YAN Zhuowen 1, YUAN Xiaoming 1, YUAN Jinyuan 2, LI Ruishan 1, WU Xiaoyang 1, YANG Yang 3, LIU Hanlong 3
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source