Results 81 to 90 of about 2,852,859 (310)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A Time–Frequency Domain Analysis Method for Variable Frequency Hopping Signal
SensorsA variable frequency hopping (VFH) signal is a kind of frequency hopping (FH) signal that varies both in frequency and dwell time. However, in radio surveillance, the existing methods for unidentified signals using VFH cannot be effectively handled.
Zhengzhi Zeng +3 more
doaj +1 more source
Application of time-frequency spectral analysis methods
Trudy Odesskogo Politehničeskogo Universiteta, 2015 In this article the limited application of the non-stationary signals spectra classical analysis using the Fourier transform is substantiated. It is shown that Fourier transform has benefits at periodic signals analysis and limitations when non ...
Yuriy K. Filipsky +2 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Time–frequency analysis using spiking neural network
Neuromorphic Computing and EngineeringTime–frequency analysis plays a crucial role in various fields, including signal processing and feature extraction. In this article, we propose an alternative and innovative method for time–frequency analysis using a biologically inspired spiking neural ...
Moshe Bensimon +3 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
INSTANTANEOUS FREQUENCY ESTIMATION USING A LEAST SQUARES TIME-FREQUENCY METHOD
Electrica, 2004 We present a method for estimating the instantaneous frequency of a signal. This method involves the calculation of a time-frequency energy density of the signal, then obtaining an instantaneous frequency estimation from this joint density.
Mahmut ÖZTÜRK, Aydın AKAN
doaj +2 more sources
Frontiers in Signal ProcessingDuring cardiac arrhythmia, the heart frequency is an important physiological parameter that can be identified by analyzing electrocardiogram (ECG) signals.
Laura Diaz-Maue +6 more
doaj +1 more source