Results 101 to 110 of about 3,293,193 (265)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Building with Time, History, and Resilience at Yale

open access: yesArchitectural Histories, 2019
This article examines Louis Kahn’s design for the New Yale Art Gallery as an exemplar of ‘building-in-time.’ The novel design breaks formally with then modernist-free architecture of the Yale campus, and yet complements and completes the existing ...
Marvin Trachtenberg
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Seoul Museum of History Seoul through Space and Time

open access: yes, 2019
พิพิธภัณฑ์ประวัติศาสตร์กรุงโซล มีเรื่องราวแบ่งเป็นเล่มย่อยได้ 11 เล่ม 1) แนะนำเกี่ยวกับประวัติศาสตร์พิพิธภัณฑ์กรุงโซล 2) วัตถุพิพิธภัณฑ์ 3) นิทรรศการถาวร 4) นิทรรศถาวร 5) ผลงานการวิจัย 6) การอนุรักษ์เชิงวิทยาการ 7) ความร่วมมือและแลกเปลี่ยนกับต่างประเทศ 8)
Seoul Museum of History
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Rethinking Time’s Arrow: Bergson, Deleuze and the Anthropology of Time [PDF]

open access: yes, 2008
Since the early 1970s, time has come to the fore as a constitutive element of social analysis in the guise of what I term here 'fluid time'. Anthropologists of multiple theoretical persuasions now take for granted that social life exists in 'time', 'flow'
Matt Hodges, Hodges, Matt
core   +1 more source

Time and History in Hegel’s Phenomenology of Spirit [PDF]

open access: yesIdeas y Valores, 2007
Resumen:En este artículo se presenta una interpretación de las tesis fundamentales de Hegel en la Fenomenología del Espíritu acerca de la relación entre tiempo, historia y filosofía especulativa o ciencia.
Luis Mariano De La Maza
doaj  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Evidence-based history taking under "time constraint"

open access: yesJournal of Research in Medical Sciences, 2011
Physicians all through the world visit patients under time limitations. The most important troubled clinical skill under "time constraint" is the diagnostic approach. In this situation, clinicians need some diagnostic approaches to reduce both diagnostic
Alireza Moayyeri   +3 more
doaj  

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