Results 111 to 120 of about 4,194,806 (302)

Estimation of wind force time-history using limited floor acceleration responses by modal analysis

Journal of Fluids and Structures
Time-history analyses are usually performed to design and examine the performance of tall structures subjected to strong wind loading. An accurate estimate of the time history of wind forces is required to carry out time-history analysis. However, previous studies conducted to estimate the time-history of wind forces require a lot of priori information,
Daiki Sato, Razelle Dennise A. Soriano, Alex Shegay, Kou Miyamoto, Jinhua She, Kazuhiko Kasai   +5 more
openaire   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Pseudosteady-state analysis of nonlinear aircraft maneuvers [PDF]

An analytical method was developed for studying the combined effects of rotational coupling and nonlinear aerodynamics on aircraft response for specified control inputs.
Johnson, K. G., Schy, A. A., Young, J. W.   +2 more
core   +1 more source

Dynamic Response of Structures with TMD [PDF]

, 2013
A Tuned Mass Damper (TMD) is a device consisting of a mass, a spring and a viscous damper attached to a vibrating main system. The principles of it are classic but applying them has become possible only after the progress of other related fields like ...
Brisid Isufi, Luan Murtaj
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Local strain redistribution corrections for a simplified inelastic analysis procedure based on an elastic finite-element analysis [PDF]

Strain redistribution corrections were developed for a simplified inelastic analysis procedure to economically calculate material cyclic response at the critical location of a structure for life prediction proposes. The method was based on the assumption
Hwang, S. Y., Kaufman, A.
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The Influence of Vertical Ground Motion on the Design of Common R/C Frames

Applied Sciences
In this article, the response of reinforced concrete frames concurrently subjected to both horizontal and vertical seismic motions is assessed. The article is not limited to the variation in response quantities but aims to identify which specific design ...
Grigorios Manoukas, Vasilios Tsiggelis
doaj   +1 more source