Results 121 to 130 of about 4,213,243 (302)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Opting out of the great inflation: German monetary policy after the breakdown of Bretton Woods [PDF]

During the turbulent 1970s and 1980s the Bundesbank established an outstanding reputation in the world of central banking. Germany achieved a high degree of domestic stability and provided safe haven for investors in times of turmoil in the international
Beyer, Andreas, Gaspar, Vítor, Gerberding, Christina, Issing, Otmar   +3 more
core   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Influence of Vertical Ground Motion on the Design of Common R/C Frames

Applied Sciences
In this article, the response of reinforced concrete frames concurrently subjected to both horizontal and vertical seismic motions is assessed. The article is not limited to the variation in response quantities but aims to identify which specific design ...
Grigorios Manoukas, Vasilios Tsiggelis
doaj   +1 more source

Survey of impact damper performance [PDF]

An overall picture of the impact damper is obtained by using time-history solutions of the system motion for the oscillator in free decay. The impactor behavior depends very strongly on oscillator amplitude, and free decay can sample the full range of ...
Brown, Gerald V.
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Improving Loss Estimation for Woodframe Buildings. Volume 2: Appendices [PDF]

, 2002
This report documents Tasks 4.1 and 4.5 of the CUREE-Caltech Woodframe Project. It presents a theoretical and empirical methodology for creating probabilistic relationships between seismic shaking severity and physical damage and loss for buildings in ...
Beck, James L., Boyd, Tom, Porter, Keith A., Scawthorn, Charles R., Seligson, Hope A., Tobin, L. Thomas, Young, Ray   +6 more
core  

Accelerated expansion from ghost-free bigravity: a statistical analysis with improved generality

, 2013
We study the background cosmology of the ghost-free, bimetric theory of gravity. We perform an extensive statistical analysis of the model using both frequentist and Bayesian frameworks and employ the constraints on the expansion history of the Universe ...
A Felice De, A Lewis, AG Riess, AR Liddle, C Blake, C Burrage, C Rham de, C Rham de, C Rham de, C Rham de, C Rham de, C Rham de, C Rham de, C Rham de, C Rham de, C Rham de, D Boulware, D Comelli, D Comelli, D Comelli, D Comelli, D Gamerman, D Langlois, E Komatsu, EJ Copeland, F Beutler, F Feroz, F Feroz, G Cowan, G D’Amico, G D’Amico, GJ Feldman, H Motohashi, J Beltran Jimenez, J Frieman, J Martin, J Neyman, J Skilling, K Hinterbichler, K Hinterbichler, K Koyama, K Koyama, K Koyama, L Berezhiani, M Berg, M Fasiello, M Fierz, M Hobson, M Strauss von, Marit Sandstad, MF Paulos, MS Volkov, MS Volkov, N Khosravi, N Suzuki, N Tamanini, R Trotta, R Trotta, R Trotta, S Hassan, S Hassan, S Hassan, S Hassan, S Hossenfelder, S Nojiri, S Perlmutter, S Weinberg, SF Hassan, T Clifton, Tomi Sebastian Koivisto, TS Koivisto, V Baccetti, V Baccetti, V Baccetti, V Mukhanov, WA Rolke, WJ Percival, Y Akrami, Y Akrami, Yashar Akrami   +79 more
core   +1 more source