Results 141 to 150 of about 4,213,243 (302)

A Fast Method for the Acceleration Response Analysis of Two-Dimensional Sites Under Seismic Excitations

Applied Sciences
The mode superposition method has been widely used for the seismic response analysis of two-dimensional (2D) sites to enhance computational efficiency. However, this method lacks a guideline of modal truncation to control errors of acceleration responses.
Hongkai Chen, Yi Yong, Xueju Li, Danguang Pan   +3 more
doaj   +1 more source

A Quasi-Steady Flexible Launch Vehicle Stability Analysis Using Steady CFD with Unsteady Aerodynamic Enhancement [PDF]

, 2011
Launch vehicles frequently experience a reduced stability margin through the transonic Mach number range. This reduced stability margin is caused by an undamping of the aerodynamics in one of the lower frequency flexible or rigid body modes.
Bartels, Robert E.
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Seismic performance evaluation of space-frame structures using nonlinear static and time-history analyses

Niğde Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi
Space-frame structures are extensively used in modern architecture and engineering due to their high load-bearing efficiency, lightweight nature, and suitability for large-span applications.
Fooad Karimi Ghaleh Jough, Sasan Babaei
doaj   +1 more source

Damped free motion of rocking specimens in non-linear time history response analysis

, 2017
In dynamic soil-structure interaction (SSI), the structure such as a building, the sway of the foundation and the rocking on ground, during an earthquake, are usually analyzed without coupled system. In this paper, assuming a restoring force - displacement characteristics for rocking, while the structure and the sway on the
Inukai, Mizuo, Azuhata, Tatsuya
openaire   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Calculating quench propagation with ANSYS® [PDF]

, 2002
A commercial Finite-Element-Analysis program, ANSYS®, is widely used in structural and thermal analysis. With the program's ability to include nonlinear material properties and import complex CAD files, one can generate coil geometries and simulate ...
Caspi, S, Chiesa, L, Ferracin, P, Gourlay, SA, Hafalia, R, Hinkins, R, Lietzke, AF, Prestemon, S   +7 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source