Results 151 to 160 of about 1,321,762 (253)

Effect of Intraoperative Low-Dose Lidocaine Administration on the Consumption of Mivacurium During Gynecological Laparoscopic Surgery: A Prospective Clinical Study. [PDF]

Drug Des Devel Ther
Fu JP, Zhou YH, Li SX, Yang YJ, Wang Q, Lei W, Shen JJ, Chen YL, Xu LL.   +8 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Repurposing anti-retroviral drugs to treat NF2-related tumours: a protocol for a phase 0 trial (RETREAT). [PDF]

BMJ Open
Campbell S, Beaney K, Hosking J, Sorrell L, Allgar V, Aspinall PJ, Ammoun S, Evans DG, Hanemann CO, Kingdon S.   +9 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Identification of Prognostic Risk Factors in Older Patients With Extensive-Stage Small Cell Lung Cancer. [PDF]

Cancer Med
Liu J, Liu X, Li X, Liu N, Wang B, Feng L, Fan Z, Wang L, Han J, Zhang X, Jin H, Li D, Liu Y, Zuo J, Wang Y.   +14 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Early ctDNA Dynamics Predict Response to Mosperafenib in BRAF V600-Mutant Metastatic Colorectal Cancer. [PDF]

Cancer Res Commun
Serrano-Serrano ML, Godfried Sie C, Bechter O, Pretelli G, Vieito M, Fontana E, Han CH, Castañón Álvarez E, Matos I, Pinato DJ, Moreno I, Eefsen RL, Plummer R, Dummer R, Prenen H, Sutton J, Cinato E, Schnetzler G, Keshelava N, Roller A.   +19 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Joint effects and dynamic trajectories of metabolic insulin resistance and systemic inflammation in the risk of renal cell carcinoma: a UK Biobank cohort analysis. [PDF]

World J Urol
Chen S, Jiang F, Wang J, Li J, Tan W, Ren J, Zhang M, Feng D.   +7 more
europepmc   +1 more source

Time History and Response Spectrum Analysis of Vertically Irregular R.C. Building Frames

International Journal of Modern Trends in Engineering & Research, 2017
openaire   +1 more source