Results 51 to 60 of about 1,319,627 (254)

Dynamic response analysis of truss bridges under the effect of moving vehicles

Journal of Materials and Engineering Structures, 2022
With the characteristics of heavy and concentrated loads, the influence of moving loads on the dynamic response of the bridges is significant. Therefore, in this paper, the dynamic response of a large-scale truss bridge is studied to consider the effect ...
Tung Xuan NGUYEN, Quyet Huy NGUYEN, Hai Manh NGUYEN, Long Ngoc NGUYEN, Hoa Ngoc TRAN, Thanh Bui TIEN   +5 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Anti-seismic Performance Comparison of Response Spectrum Analysis and Time History Analysis Based on Computer Big Data

Journal of Physics: Conference Series, 2020
Abstract This paper introduces the methods and principles of response spectrum analysis and time history analysis of seismic performance of structures based on computer big data. In order to discuss the common ground and the consistency of the calculated results between the two methods, the response spectrum analysis, time history ...
Wenman Du, Shanshan Zhang, Qian Li
openaire   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Performance-based seismic assessment of vulnerability of dam using time history analysis

MATEC Web of Conferences, 2018
The current performance-based seismic assessment procedure can be computationally intensive as it requires many time history analyses (THA) each requiring time intensive post-processing of results.
Elmrabet Oumnia, Boubel Hasnae, Mehdi Echebba El, Rougui Mohamed, Mouhat Ouadia   +4 more
doaj   +2 more sources

Rapid response calculation of LNG cargo containment system under sloshing load using wavelet transformation

International Journal of Naval Architecture and Ocean Engineering, 2013
Reliable strength assessment of the Liquefied Natural Gas (LNG) cargo containment system under the sloshing impact load is very difficult task due to the complexity of the physics involved in, both in terms of the hydrodynamics and structural mechanics ...
Yooil Kim
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Investigation of Lateral and Longitudinal Deformation of Submarine Nuclear Power Plant Water-Intake Tunnel on Non-Uniform Soft Soil during Earthquake

Applied Sciences
The safety-grade water-intake immersed tunnel plays a vital role in the nuclear power cooling system, and its seismic safety is crucial. This paper employs the response displacement method and dynamic time-history analysis using the finite element ...
Jie Zhao, Bo Qian, Changjiang Gan, Jianshan Wang, Yanli Peng   +4 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source