Results 111 to 120 of about 1,528,850 (317)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Time-varying integration, the euro and international diversification strategy [PDF]

open access: yes
This paper investigates the impact of globalization and integration on the relative benefits of country and industry diversification. Unlike previous models, our factor model allows asset exposures to vary with both structural changes and temporary ...
Lieven Baele, Koen Inghelbrecht
core  

"The Sociology of European Integration" [PDF]

open access: yes, 2007
[From the introduction]. In recent critical literature reviews we have attempted to round up and summarise the existing ‘sociological’ style literature, as well as point to new and ongoing work that seems to advance a new agenda for sociology in EU ...
Guiraudon, Virginie,, Favell, Adrian.
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Testing for seasonal fractional integration in quarterly time series

open access: yesStatistica, 2007
Many series such as agricultural commodity prices and economic and financial series, exhibit strong dependence-long memory property. Since many time series also exhibit seasonal patterns, this paper considers a number of tests - namely Hassler's ...
Paramsothy Silvapulle
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Dynamics of Equity Market Integration in Europe: Evidence of Changes over time and with events. [PDF]

open access: yes
This paper examines the integration of European equity markets over the 1985-2002 period using a relatively new cointegrating technique that assesses how the level of integration in equity price levels changes over time. This procedure is supplemented by
Cal Muckley   +2 more
core  

Integration: An Ever-Closer Challenge. CEPS Working Document, No. 258, 9 February 2007 [PDF]

open access: yes, 2007
This article argues for closer integration to be a key part of the EU's migration policy. It accepts that migration is necessary for a prosperous Europe and looks at the role of the EU and how best to integrate immigrants.
Bertozzi, Stefano.
core  

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