We synthesized four novel carprofen‐derived carbazole–acylthiourea propanamides with selective antimicrobial activity against Staphylococcus aureus, Enterococcus faecalis, and Candida albicans. Compound 1a provides combined antioxidant and antihemolytic protection.
Carmen Limban +17 more
wiley +1 more source
Analytical Methods for the Determination of Diamorphine (Heroin) in Biological Matrices: A Review. [PDF]
Al-Asmari AI.
europepmc +1 more source
Abstract De novo protein design often produces thermostable proteins that denature above 100°C, which complicates the analysis of their stability. Thermostable proteins can be unfolded by combined chemical and thermal denaturation followed by global analysis of multiple melting curves.
Vili Lampinen +7 more
wiley +1 more source
Enhanced fault protection coordination in wind-solar distribution grids utilizing improved hyper spherical search based optimization. [PDF]
Rath SS +7 more
europepmc +1 more source
A Unified Block‐Modal Framework for Inverse Source Problems in Heat and Mass Transfer
ABSTRACT This work presents a unified block–modal framework for inverse source identification in linear diffusive problems arising in heat and mass transfer. Starting from a general parabolic model with mixed boundary operators, the Classical Integral Transform Technique is employed to project the dynamics onto an orthonormal eigenbasis, yielding a ...
André J. P. de Oliveira +5 more
wiley +1 more source
Enhancing Coordination Efficiency with Fuzzy Monte Carlo Uncertainty Analysis for Dual-Setting Directional Overcurrent Relays Amid Distributed Generation. [PDF]
Al-Bhadely F, İnan A.
europepmc +1 more source
A modular multi‐domain framework couples electrical and thermal subsystems to simulate floating photovoltaic performance. Four configurations, pairing two electrical (EF, PMPP) and two thermal (MLTM, FDM) models, are validated against Orlando OEDI field data.
Oreoluwa Lawale +2 more
wiley +1 more source
Multi-scale modelling of location- and frequency-dependent synaptic plasticity induced by repetitive magnetic stimulation in the dendrites of pyramidal neurons. [PDF]
Hananeia N +6 more
europepmc +1 more source
Scaffold Hopping Provides Liver X Receptor Agonist With Preference for the β Subtype
A scaffold hopping strategy was pursued to enhance the binding pocket engagement and β‐subtype selectivity of liver X receptor agonist 2. The resulting spirocyclic lead compound, (S)‐7, demonstrates superior potency, enhanced potency‐based selectivity for LXRβ, and improved microsomal stability over the existing scaffold.
Annette Kärcher +5 more
wiley +1 more source
Air Conditioning Load Data Generation Method Based on DTW Clustering and Physically Constrained TimeGAN. [PDF]
Li Y +5 more
europepmc +1 more source

