Results 101 to 110 of about 213 (180)

Novel Carbazole–Acylthiourea Derivatives: Synthesis, Antimicrobial, Antioxidant, Hemocompatibility, Cytotoxicity, and ADME‐Tox Profiling

open access: yesChemistryOpen, Volume 15, Issue 11, November 2026.
We synthesized four novel carprofen‐derived carbazole–acylthiourea propanamides with selective antimicrobial activity against Staphylococcus aureus, Enterococcus faecalis, and Candida albicans. Compound 1a provides combined antioxidant and antihemolytic protection.
Carmen Limban   +17 more
wiley   +1 more source

Global analysis of thermal and chemical denaturation using CheMelt: Thermodynamic dissection of highly thermostable de novo designed proteins

open access: yesProtein Science, Volume 35, Issue 11, November 2026.
Abstract De novo protein design often produces thermostable proteins that denature above 100°C, which complicates the analysis of their stability. Thermostable proteins can be unfolded by combined chemical and thermal denaturation followed by global analysis of multiple melting curves.
Vili Lampinen   +7 more
wiley   +1 more source

A Unified Block‐Modal Framework for Inverse Source Problems in Heat and Mass Transfer

open access: yesInternational Journal for Numerical Methods in Engineering, Volume 127, Issue 19, 15 October 2026.
ABSTRACT This work presents a unified block–modal framework for inverse source identification in linear diffusive problems arising in heat and mass transfer. Starting from a general parabolic model with mixed boundary operators, the Classical Integral Transform Technique is employed to project the dynamics onto an orthonormal eigenbasis, yielding a ...
André J. P. de Oliveira   +5 more
wiley   +1 more source

A Multi‐Domain System‐Level Framework for Floating Photovoltaic Systems With Comparative Analysis of Thermal Configurations

open access: yesSolar RRL, Volume 10, Issue 19, 15 October 2026.
A modular multi‐domain framework couples electrical and thermal subsystems to simulate floating photovoltaic performance. Four configurations, pairing two electrical (EF, PMPP) and two thermal (MLTM, FDM) models, are validated against Orlando OEDI field data.
Oreoluwa Lawale   +2 more
wiley   +1 more source

Scaffold Hopping Provides Liver X Receptor Agonist With Preference for the β Subtype

open access: yesChemMedChem, Volume 21, Issue 19, 14 October 2026.
A scaffold hopping strategy was pursued to enhance the binding pocket engagement and β‐subtype selectivity of liver X receptor agonist 2. The resulting spirocyclic lead compound, (S)‐7, demonstrates superior potency, enhanced potency‐based selectivity for LXRβ, and improved microsomal stability over the existing scaffold.
Annette Kärcher   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy