Results 61 to 70 of about 411,121 (308)

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Yelets uprising of 1606 in the history of the Time of Troubles [PDF]

open access: yes, 2014
The article was submitted on 15.05.2014.Having analyzed the few surviving documents and memoirs of the summer of 1606 in Russia and critically considered with their help of fables, manuscripts and memoirs, the author concludes that the popular movement ...
Tyumentsev, I.   +1 more
core  

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

open access: yesFEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Révolution française de 1789 contre Temps des troubles russe

open access: yesRevue des études slaves, 2019
Interpreting the Russian Revolution of 1917: French Revolution of 1789 versus Russian-Time of Troubles The French Revolution of 1789 is a common topic in the language and in the symbols of the Russian Revolution of 1917.
Catherine Depretto
doaj   +1 more source

The USSR and The GDR: Mutual Collapse

open access: yes, 2020
The Soviet Union had a number of satellite states, where communist puppet regimes were propped up in order to serve the interests of the Soviet Union. The Eastern Bloc was established with the goal of spreading the Soviet style of government, regardless ...
Alessi, Jessica M.
core  

Love and Friendship in the Lysis and the Symposium: Human and Divine [PDF]

open access: yes, 2008
The paper claims that we cannot understand properly Platonic conception of love and friendship unless we read the Lysis in the light of the Symposium and vice verse.
Jinek, Jakub
core  

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

open access: yesFEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig   +7 more
wiley   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

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