Results 61 to 70 of about 198,483 (176)

A Discrete Choice Experiment to Derive Health Utilities for Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency in France

Patient Related Outcome Measures, 2022
Adam B Smith,1 Andria Hanbury,1 Jennifer A Whitty,2 Igor Beitia Ortiz de Zarate,3 Florence Hammes,3 Gérard de Pouvourville,4 Katharina Buesch5 1York Health Economics Consortium, University of York, York, UK; 2Norwich Medical School, University of East ...
Smith AB, Hanbury A, Whitty JA, Beitia Ortiz de Zarate I, Hammes F, de Pouvourville G, Buesch K   +6 more
doaj  

Choice over Time [PDF]

In the last twenty years a growing body of experimental evidence has posed a challenge to the standard Exponential Discounting Model of choice over time.
Marco Mariotti, Paola Manzini
core  

Neoliberalising bioethics: Bias, enhancement and economistic ethics [PDF]

, 2008
In bioethics there is an ongoing debate about the ethical case for human enhancement through new biomedical technologies. In this debate there are both supporters and opponents of human enhancement technologies such as genetic improvements of cognitive ...
Birch, Kean
core   +1 more source

Discounting of delayed payoffs (Rzecz o dyskontowaniu odroczonych wyplat) [PDF]

The paper presents empirical results on the discounting of delayed payoffs which show that: (1) the best approximation of the discounting process is a hyperbolic function, (2) (both animals and humans) can reverse their preferences in time.
Piotr Zielonka, Przemyslaw Sawicki, Rafal Weron   +2 more
core  

Alteration of hyperpolarization-activated cation current-mediated metaplasticity contributes to electroconvulsive shock-induced learning and memory impairment in depressed rats

Frontiers in Psychiatry
BackgroundAccompanied by a rapid and effective antidepressant effect, electroconvulsive shock (ECS) can also induce learning and memory impairment. Our previous research reported that metaplasticity is involved in this process.
Li Ren, Jian Yu, Hengsheng Chen, Jie Luo, Feng Lv, Su Min   +5 more
doaj   +1 more source

Anti-Anxiety Effects of Essential Oil Microemulsion in Chronic Unpredictable Mild Stress-Induced Rats: Preparation, Characterization, and Mechanisms

Molecules
Anxiety disorders, as common neurological diseases in clinical practice, often coexist with depression. Epidemiological surveys indicate that approximately 85% of patients with depression exhibit significant anxiety symptoms. This comorbid state not only
Wenxia Tang, Pan Jiang, Ke Hu, Duo Mei, Qinghao Jiao, Yan Li, Yanping Deng, Jun Wang, Ran Gao, Xin Chen, Jie Yu   +10 more
doaj   +1 more source

Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. [PDF]

, 2019
TMEM16F is activated by elevated intracellular Ca2+, and functions as a small-conductance ion channel and as a phospholipid scramblase. In contrast to its paralogs, the TMEM16A/B calcium-activated chloride channels, mouse TMEM16F has been reported as a ...
Han, Tina W, He, Mu, Jan, Lily Yeh, Jan, Yuh Nung, Ye, Wenlei   +4 more
core   +2 more sources

How do animals weigh conflicting information about reward sources over time? Comparing dynamic averaging models

Animal Cognition
Optimal foraging theory suggests that animals make decisions which maximize their food intake per unit time when foraging, but the mechanisms animals use to track the value of behavioral alternatives and choose between them remain unclear. Several models
Jack Van Allsburg, Timothy A. Shahan
doaj   +1 more source

Rationality and dynamic consistency under risk and uncertainty [PDF]

, 2013
For choice with deterministic consequences, the standard rationality hypothesis is ordinality - i.e., maximization of a weak preference ordering. For choice under risk (resp.
Hammond, Peter J., Zank, Horst
core   +2 more sources

Reversal of anxiety-like depression induced by chronic corticosterone by crocin I and surface-enhanced Raman spectroscopy monitoring of plasma metabolites

Frontiers in Pharmacology
Anxiety disorders and depression often co-occur and lack broadly available treatments. Gardenia extract significantly associated with treatment of anxiety-like depression.
Dandan Zhang, Zhuodi Wu, Doudou Yang, Guanjie Zhao, Yanru Zhang, Weifeng Mou, Yinku Liang   +6 more
doaj   +1 more source