Results 221 to 230 of about 11,420,922 (288)

Time-scale invariant contingency yields one-shot reinforcement learning despite extremely long delays to reinforcement. [PDF]

Proc Natl Acad Sci U S A
Gallistel CR, Shahan TA.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mechanoreceptive Aβ primary afferents discriminate naturalistic social touch inputs at a functionally relevant time scale. [PDF]

IEEE Trans Affect Comput
Xu S, Hauser SC, Nagi SS, Jablonski JA, Rezaei M, Jarocka E, Marshall AG, Olausson H, McIntyre S, Gerling GJ.   +9 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Impaired long-range excitatory time scale predicts abnormal neural oscillations and cognitive deficits in Alzheimer's disease. [PDF]

Alzheimers Res Ther
Verma P, Ranasinghe K, Prasad J, Cai C, Xie X, Lerner H, Mizuiri D, Miller B, Rankin K, Vossel K, Cheung SW, Nagarajan SS, Raj A.   +12 more
europepmc   +1 more source

Jitter solution in parameter identification based on cross-time scale fusion algorithm of lithium-ion batteries. [PDF]

Heliyon
Su X, Ge Y, Qiao X.
europepmc   +1 more source

Experimental Evidence for Millisecond-Timescale Structural Evolution Following the Microsecond-Timescale Folding of a Small Protein. [PDF]

Phys Rev Lett
Wilson CB, Yau WM, Tycko R.
europepmc   +1 more source

Identification of Damping of Spruce Wood (Picea abies) under Various Levels of Moisture Content Using Time-Scale Decomposition. [PDF]

Polymers (Basel)
Merhar M.
europepmc   +1 more source

Multi-Time-Scale Optimal Scheduling Strategy for Marine Renewable Energy Based on Deep Reinforcement Learning Algorithm. [PDF]

Entropy (Basel)
Xu R, Lin F, Shao W, Wang H, Meng F, Li J.   +5 more
europepmc   +1 more source