Results 61 to 70 of about 3,745,577 (266)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

New Criteria for Oscillation of Advanced Noncanonical Nonlinear Dynamic Equations

Mathematics
In this study, novel criteria are derived to ensure the oscillation of solutions in nonlinear advanced noncanonical dynamic equations. The obtained results are reminiscent of the criteria proposed by Hille and Ohriska for canonical dynamic equations ...
Taher S. Hassan, Rami Ahmad El-Nabulsi, Naveed Iqbal, Amir Abdel Menaem   +3 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Efficient resource allocation for D2D-enabled social IoT networks: A tripartite and time-scale optimization approach

Intelligent and Converged Networks
In the densification of Device-to-Device (D2D)-enabled Social Internet of Things (SIoT) networks, improper allocation of resources can lead to high interference, increased signaling overhead, latency, and disruption of Channel State Information (CSI). In
Saurabh Chandra, Rajeev Arya, Maheshwari Prasad Singh   +2 more
doaj   +1 more source

Oscillation of second order neutral dynamic equations with distributed delay

Electronic Journal of Qualitative Theory of Differential Equations, 2016
In this paper, we establish new oscillation criteria for second order neutral dynamic equations with distributed delay by employing the generalized Riccati transformation.
Qiaoshun Yang, Zhiting Xu, Ping Long
doaj   +1 more source

Integration on time scales

Journal of Mathematical Analysis and Applications, 2003
In this paper, the author defines the Riemann and Lebesgue integrals (more precisely, the Riemann and Lebesgue \(\Delta\)-integrals and \(\nabla\)-integrals) on time scales and studies their properties and relationship. In particular, the author presents results concerning the lower and upper Darboux sums, the Riemann sums, the Riemann and Lebesgue ...
openaire   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Oscillatory behavior of higher-order neutral type dynamic equations

Electronic Journal of Qualitative Theory of Differential Equations, 2013
The oscillation behavior of solutions for higher-order delay dynamic equations of neutral type is investigated by making use of comparison with second-order dynamic equations.
Said Grace, Raziye Mert, Agacik Zafer
doaj   +1 more source