Results 71 to 80 of about 11,420,922 (288)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Role of relaxation time scale in noisy signal transduction
, 2014 Intracellular fluctuations, mainly triggered by gene expression, are an inevitable phenomenon observed in living cells. It influences generation of phenotypic diversity in genetically identical cells.
Banik, Suman K. +2 more
core +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Long-Time Data Storage: Relevant Time Scales [PDF]
Challenges, 2011 Dynamic processes relevant for long-time storage of information about human kind are discussed, ranging from biological and geological processes to the lifecycle of stars and the expansion of the universe. Major results are that life will end ultimately and the remaining time that the earth is habitable for complex life is about half a billion years. A
openaire +4 more sources
Time fractals and discrete scale invariance with trapped ions
, 2019 We show that a one-dimensional chain of trapped ions can be engineered to produce a quantum mechanical system with discrete scale invariance and fractal-like time dependence.
Frame, Dillon +7 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
On the existence and uniqueness of solution to Volterra equation on a time scale
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2019 Using a global inversion theorem we investigate properties of the following ...
Kluczyński Bartłomiej
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Nabla derivatives associated with nonlinear control systems on homogeneous time scales
Nonlinear Analysis, 2016 The backward shift and nabla derivative operators, defined by the control system on homogeneous time scale, in vector spaces of one-forms and vector fields are introduced and some of their properties are proven.
Zbigniew Bartosiewicz +5 more
doaj +1 more source