Results 71 to 80 of about 3,595,948 (318)

Avoidance Control on Time Scales [PDF]

Journal of Optimization Theory and Applications, 2010
We consider dynamic systems on time scales under the control of two agents. One of the agents desires to keep the state of the system out of a given set regardless of the other agent's actions. Leitmann's avoidance conditions are proved to be valid for dynamic systems evolving on an arbitrary time scale.
Pawłuszewicz, E., Torres, D.F.M.
openaire   +5 more sources

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Estimates on some power nonlinear Volterra-Fredholm type dynamic integral inequalities on time scales

Advances in Difference Equations, 2017
In this paper, some explicit bounds on solutions to a class of new power nonlinear Volterra-Fredholm type dynamic integral inequalities on time scales are established, which can be used as effective tools in the study of certain dynamic equations ...
Jiangfeng Wang, Fanwei Meng, Juan Gu
doaj   +1 more source

The Time Scale of Evolutionary Innovation

PLoS Computational Biology, 2014
A fundamental question in biology is the following: what is the time scale that is needed for evolutionary innovations? There are many results that characterize single steps in terms of the fixation time of new mutants arising in populations of certain size and structure.
Chatterjee, Krishnendu, Pavlogiannis, Andreas, Adlam, Ben, Nowak, Martin   +3 more
openaire   +7 more sources

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

OPTICAL TIME SCALE

Le Journal de Physique Colloques, 1981
The production of a time scale based on the use of an oscillation period of a highly stable laser is first reported. The new time standard allows to transfer frequency characteristics of a highly stable laser in the frequency range from 0 to 1014 Hz with no losses in accuracy.
openaire   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Of Scales and Times

21: Inquiries into Art, History, and the Visual
21: Inquiries into Art, History, and the Visual, Bd. 5 Nr. 1 (2024): 21: Inquiries into Art, History, and the Visual.
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source