Results 91 to 100 of about 802,210 (308)

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

Kwong-Wong-type integral equation on time scales

open access: yesElectronic Journal of Differential Equations, 2011
Consider the second-order nonlinear dynamic equation $$ [r(t)x^Delta(ho(t))]^Delta+p(t)f(x(t))=0, $$ where $p(t)$ is the backward jump operator. We obtain a Kwong-Wong-type integral equation, that is: If $x(t)$ is a nonoscillatory solution of the ...
Baoguo Jia
doaj  

Hamiltonian Systems on Time Scales

open access: yesJournal of Mathematical Analysis and Applications, 2000
The authors investigate linear Hamiltonian systems on time scales \[ x^{\Delta }={\mathcal H}(t)x, \] where \({}^{\Delta }\) denotes the generalized (time scale) derivative, \(x\in \mathbb{R}^{2n}\), \({\mathcal H}\) is a \(2n\times 2n\) matrix satisfying \({\mathcal H}^*(t){\mathcal J}+{\mathcal J}{\mathcal H}(t)+ \mu(t){\mathcal H}^*(t){\mathcal J ...
Jerry Ridenhour   +2 more
openaire   +3 more sources

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

open access: yesMolecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo   +8 more
wiley   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

Proportional Epidemic Models on Time Scales

open access: yesJournal of Mathematical Sciences and Modelling
In this study, some epidemic models such as SI (Susceptible-Infectious), SIR (Susceptible-Infectious-Recovered), and SIS (Susceptible-Infectious-Susceptible) have been formulated using proportional derivative on time scales, and solutions have been ...
Gülcan Tokay, Emrah Yılmaz
doaj   +1 more source

Existence, Uniqueness and Stability of Nonlinear Implicit Fractional Dynamical Equation with Impulsive condition on Time Scales

open access: yesNonautonomous Dynamical Systems, 2019
The main motive of this research article is to establish the existence, uniqueness and stability results for the non-linear fractional differential equation with impulsive condition on time scales.
Kumar Vipin, Malik Muslim
doaj   +1 more source

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