Results 131 to 140 of about 2,965,478 (248)

Adaptation to changes in COVID-19 pandemic severity: Across older adulthood and time scales. [PDF]

Psychol Aging, 2023
Segerstrom SC, Crosby P, Witzel DD, Kurth ML, Choun S, Aldwin CM.   +5 more
europepmc   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Emergent time scales of epistasis in protein evolution. [PDF]

Proc Natl Acad Sci U S A
Di Bari L, Bisardi M, Cotogno S, Weigt M, Zamponi F.   +4 more
europepmc   +1 more source

Optically controlling the competition between spin flips and intersite spin transfer in a Heusler half-metal on sub-100-fs time scales. [PDF]

Sci Adv, 2023
Ryan SA, Johnsen PC, Elhanoty MF, Grafov A, Li N, Delin A, Markou A, Lesne E, Felser C, Eriksson O, Kapteyn HC, Grånäs O, Murnane MM.   +12 more
europepmc   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Network Mechanisms Underlying the Regional Diversity of Variance and Time Scales of the Brain's Spontaneous Activity Fluctuations. [PDF]

J Neurosci
Ponce-Alvarez A.
europepmc   +1 more source

Modelling multiple time-scales with flexible parametric survival models. [PDF]

BMC Med Res Methodol, 2022
Batyrbekova N, Bower H, Dickman PW, Ravn Landtblom A, Hultcrantz M, Szulkin R, Lambert PC, Andersson TM.   +7 more
europepmc   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Simulating the impact of white matter connectivity on processing time scales using brain network models. [PDF]

Commun Biol
Triebkorn P, Jirsa V, Dominey PF.
europepmc   +1 more source

A Method for Autonomous Generation of High-Precision Time Scales for Navigation Constellations. [PDF]

Sensors (Basel), 2023
Yang S, Yi X, Dong R, Ren Q, Li X, Shuai T, Zhang J, Gong W.   +7 more
europepmc   +1 more source