Results 151 to 160 of about 1,023,532 (301)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Quadratic Programming Problems on Time Scales
, 2020 In this work, we formulate and solve quadratic programming problems using the time scales approach. This approach unifies discrete and continuous quadratic programming models and extends them to other cases “in between.” The formulation of the primal as ...
Bohner, Martin, Al-Salih, Rasheed
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Theorems of Kiguradze-type and Belohorec-type revisited on time scales
Electronic Journal of Differential Equations, 2015 This article concerns the oscillation of second-order nonlinear dynamic equations. By using generalized Riccati transformations, Kiguradze-type and Belohorec-type oscillation theorems are obtained on an arbitrary time scale.
Hongwu Wu, Baoguo Jia, Lynn Erbe
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Separation of Time Scales in Weakly Interacting Diffusions. [PDF]
Arch Ration Mech AnalAdams ZP, Engel M, Gvalani RS.
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Improper integrals on time scales
, 2003 In this paper we study improper integrals on time scales. We also give some mean value theorems for integrals on time scales, which are used in the proof of an analogue of the classical Dirichlet–Abel test for improper ...
Martin Bohner, Gusein Sh. Guseinov
core +1 more source
The choice of time scales in survival analysis has implications: calendar time versus patients' time-to-event. [PDF]
BMC Med Res MethodolVilsmeier J +5 more
europepmc +1 more source