Results 131 to 140 of about 844,674 (258)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

The influence of temporal context on vision over multiple time scales. [PDF]

Elife
Lee K, Rideaux R.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

'Ion-freeze' efficiency in perovskite solar cells: time scales for ion immobilization. [PDF]

EES Solar
H Balaguera E, Marinelli Pra FJ, Das C, Torresani L, Bisquert J, Saliba M.   +5 more
europepmc   +1 more source

Time scales of adaptation to context in horizontal sound localization. [PDF]

J Acoust Soc Am, 2023
Andrejková G, Best V, Kopčo N.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Neural crest cell biology shapes lizard skull evolution across evolutionary time scales. [PDF]

Evol Lett
Horta-Lacueva Q, Uller T, Flecks M, Gabelaia M, Hipsley CA, Kirchner M, Müller J, Feiner N.   +7 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Iron-Responsive Deferasirox Release from Covalently Grafted Hydrogels on Microwires Extends Iron Chelation Time Scales. [PDF]

ACS Appl Mater Interfaces
Maleszka JA, Attah E, Tsironi I, Franklin M, Bernard B, Grant JL, Lee GM, Lewis M, Byrd S, Prasad A, Olivier JH.   +10 more
europepmc   +1 more source

Exploring Charge-Detection Mass Spectrometry on Chromatographic Time Scales. [PDF]

Anal Chem, 2023
Strasser L, Füssl F, Morgan TE, Carillo S, Bones J.   +4 more
europepmc   +1 more source