Results 41 to 50 of about 2,965,478 (248)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Sturm-Liouville operators on time scales

, 2011
We establish the connection between Sturm-Liouville equations on time scales and Sturm--Liouville equations with measure-valued coefficients. Based on this connection we generalize several results for Sturm-Liouville equations on time scales which have ...
Atkinson F., Davidson F.A., Erbe L., Gerald Teschl, Guseinov G.S., Guseinov G.S., Huseynov A., Huseynov A., Jonathan Eckhardt, Mingarelli A.B., Sun S., Teschl G., Volkmer H., Zhang C., Šimon Hilscher R.   +14 more
core   +4 more sources

Integration on time scales

Journal of Mathematical Analysis and Applications, 2003
AbstractIn this paper we study the process of Riemann and Lebesgue integration on time scales. The relationship of the Riemann and Lebesgue integrals is considered and a criterion for Riemann integrability is established.
openaire   +2 more sources

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Stability of graph communities across time scales [PDF]

, 2009
The complexity of biological, social and engineering networks makes it desirable to find natural partitions into communities that can act as simplified descriptions and provide insight into the structure and function of the overall system.
Arenas, Gfeller, J.- C. Delvenne, M. Barahona, Reichardt, S. N. Yaliraki, Strogatz   +6 more
core   +3 more sources

The Lie Brackets on Time Scales [PDF]

Abstract and Applied Analysis, 2012
The Lie derivative, which has a wide range of application in physics and geometry, is trying to be examined on time scales. Firstly, nabla Lie bracket is defined on two‐dimensional time scales. Secondly, the nabla Lie multiplication and some properties are given on the time scales.
Kusak, H., Caliskan, A.
openaire   +4 more sources

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Almost Periodic Time Scales and Almost Periodic Functions on Time Scales [PDF]

Journal of Applied Mathematics, 2015
We propose some new concepts of almost periodic time scales and almost periodic functions on time scales and give some basic properties of these new types of almost periodic time scales and almost periodic functions on time scales. We also give some comments on a recent paper by Wang and Agarwal (2014) concerning a new almost periodic time scale.
Li, Yongkun, Li, Bing
openaire   +4 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source