Results 41 to 50 of about 802,210 (308)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
The Geological Time-Scale [PDF]
Nature, 1959 SINCE my communication on this subject was written1, much has happened. Prof. J. L. Kulp2 has just published a time-scale in which the duration of the geological periods is given as follows: Ordovician, 490–430 m.y.; Silurian 430–410 m.y.; Devonian 410–355 m.y.; Mississippian 355–330 m.y.; Pennsylvanian 330–275 m.y.; Permian 275–220 m.y.; Triassic 220 ...
openaire +2 more sources
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
Steffensen's Integral Inequality on Time Scales
Journal of Inequalities and Applications, 2007 We establish generalizations of Steffensen's integral inequality on time scales via the diamond- dynamic integral, which is defined as a linear combination of the delta and nabla integrals.
Ozkan Umut Mutlu, Yildirim Hüseyin
doaj +2 more sources
Scaling in the timing of extreme events [PDF]
Chaos, Solitons & Fractals, 2015 Extreme events can come either from point processes, when the size or energy of the events is above a certain threshold, or from time series, when the intensity of a signal surpasses a threshold value. We are particularly concerned by the time between these extreme events, called respectively waiting time and quiet time.
openaire +4 more sources
FEBS Letters, EarlyView.C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi +5 more
wiley +1 more source
AIMS Mathematics, 2021 This paper deals with a class of quaternion-valued high-order Hopfield neural networks with time-varying delays and leakage delays on time scales.
Xiaofang Meng, Yongkun Li
doaj +1 more source
Applied Mathematics Letters, 2008 AbstractIn this work, we develop a time scale logarithm that preserves certain desirable algebraic properties. In particular, a nonlinear operator is developed that acts as an inverse for the time scale exponential in a certain sense. The scalar case is treated first, with a treatment of the matrix case following.
openaire +2 more sources
The Diamond Integral on Time Scales [PDF]
Bulletin of the Malaysian Mathematical Sciences Society, 2014 We define a more general type of integral on time scales. The new diamond integral is a refined version of the diamond-alpha integral introduced in 2006 by Sheng et al. A mean value theorem for the diamond integral is proved, as well as versions of Holder's, Cauchy-Schwarz's and Minkowski's inequalities.
Brito da Cruz, A. M. C. +2 more
openaire +4 more sources
FEBS Letters, EarlyView.The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley +1 more source