Results 41 to 50 of about 805,121 (258)
Some Opial-Type Inequalities on Time Scales
Abstract and Applied Analysis, 2011 We will prove some dynamic inequalities of Opial type on time scales which not only extend some results in the literature but also improve some of them. Some discrete inequalities are derived from the main results as special cases.
S. H. Saker
doaj +1 more source
Journal of Function Spaces, 2022 By the concept of fractional derivative of Riemann-Liouville on time scales, we first introduce fractional Sobolev spaces, characterize them, define weak fractional derivatives, and show that they coincide with the Riemann-Liouville ones on time scales ...
Xing Hu, Yongkun Li
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Asymptotic behavior of nonoscillatory solutions of higher-order integro-dynamic equations [PDF]
Opuscula Mathematica, 2014 In this paper, we establish some new criteria on the asymptotic behavior of nonoscillatory solutions of higher-order integro-dynamic equations on time scales.
Martin Bohner +2 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Impulsive Diffusion Equation on Time Scales
International Journal of Analysis and Applications, 2018 Application of boundary value problems (BVP’s) on an arbitrary time scale T is a fairly new and important subject in mathematics. In this study, we deal with an eigenvalue problem for impulsive diffusion equation with boundary conditions on T.
Tuba Gulsen +3 more
doaj +2 more sources
Lyapunov inequalities for time scales
Journal of Inequalities and Applications, 2002 The theory of time scales has been introduced in order to unify discrete and continuous analysis. We present a Lyapunov inequality for Sturm-Liouville dynamic equations of second order on such time scales, which can be applied to obtain a disconjugacy ...
Ridenhour Jerry +2 more
doaj
An Opial-Type Inequality on Time Scales
Abstract and Applied Analysis, 2013 We establish some new Opial-type inequalities involving higher order delta derivatives on time scales. These extend some known results in the continuous case in the literature and provide new estimates in the setting of time scales.
Qiao-Luan Li, Wing-Sum Cheung
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source