Results 71 to 80 of about 305,215 (245)

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Research on Time Synchronization of Train Communication Based on Time-sensitive Networking

Chengshi guidao jiaotong yanjiu
Objective The millisecond-level precision of NTP (network time protocol) in train communication networks has increasingly failed to meet the requirements of high traffic and deterministic transmission.
ZHANG Junxian, LIANG Rujun, HUANG Tao, ZHANG Wenyi, XU Long, XIONG Wei, ZHU Hailong, PENG Kailai   +7 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Efficient Robust Schedules (ERS) for Time-Aware Shaping in Time-Sensitive Networking

IEEE Open Journal of the Communications Society
Time-Sensitive Networking (TSN) extends Ethernet bridging with features for deterministic transmission. Periodic streams may be scheduled such that their frames hardly interfere in bridges.
Thomas Stuber, Lukas Osswald, Michael Menth   +2 more
doaj   +1 more source

Precise Clock Synchronization in High Performance Wireless Communication for Time Sensitive Networking

IEEE Access, 2018
In this paper, an enhanced precision time protocol (PTP) to enable precise clock synchronization between the nodes within an industrial wireless sensor network deployed for critical control and automation applications is proposed. As it will be shown, by
Deep Shrestha, Zhibo Pang, Dacfey Dzung
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Configuration of multi‐shaper Time‐Sensitive Networking for industrial applications

IET Networks
IEEE 802.1 Time‐Sensitive Networking (TSN) has proposed several shapers, for example, time‐aware shaper (TAS, 802.1Qbv), asynchronous traffic shaping (ATS, 802.1Qcr), credit‐based shaper (CBS, 802.1Qav), and cyclic queuing and forwarding (CQF, 802.1Qch).
Paul Pop, Konstantinos Alexandris, Tongtong Wang   +2 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Social media: Do context limitations exist? [PDF]

, 2012
Since the inception of popular social networking sites, such as MySpace, Facebook and Twitter, millions of people around the world are becoming members of their own virtual communities that continue to grow.
Fortier, Richard
core   +1 more source