Results 41 to 50 of about 3,160,678 (291)
FEBS Letters, EarlyView.The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley +2 more
wiley +1 more source
Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions
FEBS Letters, EarlyView.This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten +10 more
wiley +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Targeted model evaluations for climate services: A case study on heat waves in Bangladesh
Climate Risk Management, 2020 Though not a sufficient condition, the ability to reproduce key elements of climate variability over the historical record should be a minimum requirement for placing any confidence in a model’s climate forecasts or projections of climate change.
Hannah Nissan +2 more
doaj
On predicting climate under climate change
Environmental Research Letters, 2013 Can today’s global climate model ensembles characterize the 21st century climate in their own ‘model-worlds’? This question is at the heart of how we design and interpret climate model experiments for both science and policy support.
Joseph D Daron, David A Stainforth
doaj +1 more source
Eddies: Fluid Dynamical Niches or Transporters?–A Case Study in the Western Baltic Sea
Frontiers in Marine Science, 2019 Fluid flows in the ocean have a strong impact on the growth and distribution of planktonic communities. In this case study, we applied a Lagrangian eddy detection and tracking tool and a transfer operator approach to data from a coupled hydrodynamical ...
Rahel Vortmeyer-Kley +5 more
doaj +1 more source
Time Series Classification with Shapelet and Canonical Features
Applied Sciences, 2022 Shapelet-based time series classification methods are widely adopted models for time series classification tasks. However, the high computational cost greatly limits the practicability of the Shapelet-based methods. What is more, traditional Shapelet can
Hai-Yang Liu +3 more
doaj +1 more source
FEBS Letters, EarlyView.The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet +4 more
wiley +1 more source
FEBS Letters, EarlyView.α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley +1 more source
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source