Results 121 to 130 of about 39,145,954 (311)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

ESTSS—energy system time series suite: a declustered, application-independent, semi-artificial load profile benchmark set

Energy Informatics
This paper introduces an univariate application-independent set of load profiles or time series derived from real-world energy system data. The generation involved a two-step process: manifolding the initial dataset through signal processors to increase ...
Sebastian Günther, Jonathan Brandt, Astrid Bensmann, Richard Hanke-Rauschenbach   +3 more
doaj   +1 more source

Classification and Characterization of Vegetation Dynamics in Northeastern Mexico from 25-Year EVI Time Series

Remote Sensing
Vegetation indices are used to analyze vegetation dynamics and primary productivity. However, most studies rely on short time series and peak or integral metrics, which limit the understanding of long-term vegetation dynamics in heterogeneous areas. This
Alejandra Nahiely Espinoza-Coronado, Ángela P. Cuervo-Robayo, Jorge Víctor Horta-Vega, Arturo Mora-Olivo, Ausencio Azuara-Domínguez, Crystian S. Venegas-Barrera   +5 more
doaj   +1 more source

Multiscale entropy analysis of electroseismic time series [PDF]

Natural Hazards and Earth System Sciences, 2008
In this work we use the multiscale entropy method to analyse the variability of geo-electric time series monitored in two sites located in Mexico. In our analysis we consider a period of time from January 1995 to December 1995.
L. Guzmán-Vargas, A. Ramírez-Rojas, F. Angulo-Brown   +2 more
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Unit roots in macroeconomic time series: some critical issues [PDF]

Time-series ...
Bennett T. McCallum
core  

Nonlinear time series analysis [PDF]

, 2006
This entry for the New Palgrave covers developments in nonlinear time series analysis over the last 25 ...
Mizrach, Bruce
core  

Time series analysis of water quality parameters [PDF]

Journal of Applied Research in Water and Wastewater, 2014
Water quality is a worldwide problem which affects human beings lives fundamentally. Water scarcity is intensified in result of quality deterioration.
Abdollah Taheri Tizro, Maryam Ghashghaie, Pantazis Georgiou, Konstantinos Voudouris   +3 more
doaj