Results 51 to 60 of about 2,196,460 (253)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A Network Analysis of the Impact of the Coronavirus Pandemic on the US Economy: A Comparison of the Return and the Momentum Picture

Entropy
This study examines a cross-correlation analysis of companies included in the S&P 500 Index at three different intervals: before, during, and after the pandemic’s onset.
Janusz Miśkiewicz
doaj   +1 more source

Expectation-maximization analysis of spatial time series [PDF]

Nonlinear Processes in Geophysics, 2007
Expectation maximization (EM) is used to estimate the parameters of a Gaussian Mixture Model for spatial time series data. The method is presented as an alternative and complement to Empirical Orthogonal Function (EOF) analysis.
K. W. Smith, A. L. Aretxabaleta
doaj  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Time and memory in time series analysis [PDF]

Epidemiologia e Serviços de Saúde, 2023
Flávia Reis de Andrade, José Leopoldo Ferreira Antunes   +1 more
doaj   +1 more source

MultiCenter Interrupted Time Series Analysis: Incorporating Within and Between-Center Heterogeneity

Clinical Epidemiology, 2020
Joycelyne E Ewusie,1,2 Lehana Thabane,1 Joseph Beyene,1 Sharon E Straus,3 Jemila S Hamid1,2,4 1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; 2School of Epidemiology and Public Health ...
Ewusie JE, Thabane L, Beyene J, Straus SE, Hamid JS   +4 more
doaj  

Moving forward with time series analysis

Research & Politics, 2017
In a recent Research and Politics article, we showed that for many types of time series data, concerns about spurious relationships can be overcome by following standard procedures associated with cointegration tests and the general error correction ...
Peter K. Enns, Nathan J. Kelly, Takaaki Masaki, Patrick C. Wohlfarth   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Contextual Analysis of Financial Time Series

Mathematics
The evaluation of the financial state of small and medium-sized companies is a pressing issue today. This article introduces a novel method to evaluate a company’s financial state, implemented as a module within a decision support system.
Nadezhda Yarushkina, Aleksey Filippov, Anton Romanov   +2 more
doaj   +1 more source