Results 51 to 60 of about 523,313 (224)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

LSTM Fully Convolutional Networks for Time Series Classification

IEEE Access, 2018
Fully convolutional neural networks (FCNs) have been shown to achieve the state-of-the-art performance on the task of classifying time series sequences.
Fazle Karim, Somshubra Majumdar, Houshang Darabi, Shun Chen   +3 more
doaj   +1 more source

Variable-Length Multivariate Time Series Classification Using ROCKET: A Case Study of Incident Detection

IEEE Access, 2022
Multivariate time series classification is a machine learning problem that can be applied to automate a wide range of real-world data analysis tasks. RandOm Convolutional KErnel Transform (ROCKET) proved to be an outstanding algorithm capable to classify
Agnieszka Bier, Agnieszka Jastrzebska, Pawel Olszewski   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Sparseness-Optimized Feature Importance for Time Series Classification

IEEE Access
The literature reports a wide variety of attribution methods for explaining the predictions made by time series classification (TSC) algorithms. These post-hoc explanation methods span from model-specific to agnostic procedures that operate at different ...
Isel Grau, Gonzalo Napoles, Agnieszka Jastrzebska, Yamisleydi Salgueiro   +3 more
doaj   +1 more source

Multi-View Time Series Classification [PDF]

Proceedings of the 25th ACM International on Conference on Information and Knowledge Management, 2016
By virtue of the increasingly large amount of various sensors, information about the same object can be collected from multiple views. These mutually enriched information can help many real-world applications, such as daily activity recognition in which both video cameras and on-body sensors are continuously collecting information.
Sheng Li, Yaliang Li, Yun Fu
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Adaptive Multi-Scale Wavelet Neural Network for Time Series Classification

Information, 2021
Wavelet transform is a well-known multi-resolution tool to analyze the time series in the time-frequency domain. Wavelet basis is diverse but predefined by manual without taking the data into the consideration. Hence, it is a great challenge to select an
Kewei Ouyang, Yi Hou, Shilin Zhou, Ye Zhang   +3 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source