Results 51 to 60 of about 1,891,060 (279)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson +3 more
wiley +1 more source
Financial time series prediction using spiking neural networks. [PDF]
PLoS ONE, 2014 In this paper a novel application of a particular type of spiking neural network, a Polychronous Spiking Network, was used for financial time series prediction.
David Reid +2 more
doaj +1 more source
Bootstrap prediction intervals for power-transformed time series [PDF]
, 2001 In this paper we propose a bootstrap resampling scheme to construct prediction intervals for future values of a variable after a linear ARIMA model has been fitted to a power transformation of it.
Pascual, Lorenzo +2 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Time Series Prediction Method of Bank Cash Flow and Simulation Comparison
Algorithms, 2014 In order to improve the accuracy of all kinds of information in the cash business and enhance the linkage between cash inventory forecasting and cash management information in the commercial bank, the first moving average prediction method, the second ...
Wen-Hua Cui +2 more
doaj +1 more source
Applied Sciences, 2022 The Key Laboratory of Integrated Microsystems (IMS) of Peking University Shenzhen Graduate School has deployed a self-developed acoustic and electromagnetics to artificial intelligence (AETA) system on a large scale and at a high density in China to ...
Chenyang Wang +4 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Radial Basis Function Nets for Time Series Prediction [PDF]
International Journal of Computational Intelligence Systems, 2009 This paper introduces a novel ensemble learning approach based on recurrent radial basis function networks (RRBFN) for time series prediction with the aim of increasing the prediction accuracy. Standing for the base learner in this ensemble, the adaptive
Abdelhamid Bouchachia
doaj +1 more source
Forecasting Stock Time-Series using Data Approximation and Pattern Sequence Similarity [PDF]
, 2013 Time series analysis is the process of building a model using statistical techniques to represent characteristics of time series data. Processing and forecasting huge time series data is a challenging task.
Iyengar, S. S. +7 more
core +1 more source