Results 51 to 60 of about 428,742 (262)

Time Series and Non-Time Series Models of Earthquake Prediction Based on AETA Data: 16-Week Real Case Study

Applied Sciences, 2022
The Key Laboratory of Integrated Microsystems (IMS) of Peking University Shenzhen Graduate School has deployed a self-developed acoustic and electromagnetics to artificial intelligence (AETA) system on a large scale and at a high density in China to ...
Chenyang Wang, Chaorun Li, Shanshan Yong, Xin’an Wang, Chao Yang   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Time Series Prediction Based on Complex-Valued S-System Model

Complexity, 2020
Symbolic regression has been utilized to infer mathematical formulas in order to solve the complex prediction and classification problems. In this paper, complex-valued S-system model (CVSS) is proposed to predict real-valued time series data.
Bin Yang, Wenzheng Bao, Yuehui Chen
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Chaotic Time Series Prediction Using Immune Optimization Theory [PDF]

International Journal of Computational Intelligence Systems, 2010
To solve chaotic time series prediction problem, a novel Prediction approach for chaotic time series based on Immune Optimization Theory (PIOT) is proposed.
Yuanquan Shi, Xiaojie Liu, Tao Li, Xiaoning Peng, Wen Chen, Ruirui Zhang, Yanming Fu   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Model for non-periodic time series prediction

大数据
In practical applications, purely periodic data is relatively rare, and most data often exhibit non-periodic characteristics, making it challenging to predict or describe through simple periodic changes. Single neural network frequently encounters issues
CAO Jianwen, WEI Xingbao, YANG Yi, LI Caihong, ZHAO Wenqing   +4 more
doaj   +2 more sources