Results 101 to 110 of about 1,516,859 (293)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
EFFECTIVENESS OF REARING AND FATTENING OF LOW-WEIGHT PIGLETS DUE TO CHANGES IN THEIR FEEDING SYSTEMS [PDF]
Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural DevelopmentThe article contains the results of a study on the conservation, growth dynamics from birth to slaughter and economic efficiency of growing and fattening pigs depending on their live weight at birth and different feeding systems during the production ...
Igor MOISEI +6 more
doaj
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Reproductive Biology and EndocrinologyBackground Data sciences and artificial intelligence are becoming encouraging tools in assisted reproduction, favored by time-lapse technology incubators.
Jorge Ten +6 more
doaj +1 more source
Social Security and the Age of Retirement [PDF]
, 2010 Unlike a century ago, people expect their children to live past the age of retirement. This fact has important implications for how workers save for retirement, but has no specific implications for the retirement portion of Social Security.
David Rosnick
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
A survey of relative frequency of etiologies, time of onset, efficacy of drug therapy and risk factors for clinical neonatal seizures [PDF]
Introduction: Seizure is a common condition in neonatal period and may become first feature of neurologic dysfunction. In most cases, diagnosis of neonatal seizure and its different etiologies are based on history, clinical manifestations and ...
براک, منوچهر +3 more
core
The male to female ratio at birth [PDF]
, 2014 The factors that influence the male to female ratio at birth are legion. Males are usually born in excess and stress decreases the ratio while wellbeing and good health tends to increase it.
Grech, Victor E., Mamo, Julian
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source