Exploring the experiences and outcomes of advantaged and disadvantaged families [PDF]
This report provides further evidence of the interrelationship between age, young motherhood, family type and a range of measures of socio-economic advantage and disadvantage.
Bradshaw, Paul +2 more
core
Association of Special Supplemental Nutrition Program for Women, Infants, and Children With Preterm Birth and Infant Mortality. [PDF]
Importance:Nearly 4 in 10 expectant mothers in the United States received Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) benefits during pregnancy between 2011 and 2017.
Beltrán-Sánchez, Hiram, Soneji, Samir
core +3 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Epidemiology of gastroschisis: A population-based study in California from 1995 to 2012. [PDF]
BackgroundAlthough the incidence of gastroschisis is increasing, risk factors are not clearly identified.MethodsUsing the Linked Birth Database from the California Office of Statewide Health Planning and Development from 1995 to 2012, patients with ...
Anderson, Jamie E +6 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Growing up in rural Scotland [PDF]
Sweep 1 of GUS provides some evidence that children in rural areas may be more likely to live in favourable socio-economic circumstances than their urban counterparts.
Bradshaw, Paul +2 more
core
Population Dynamics in Spatially Heterogeneous Systems with Drift: the generalized contact process
We investigate the time evolution and stationary states of a stochastic, spatially discrete, population model (contact process) with spatial heterogeneity and imposed drift (wind) in one- and two-dimensions. We consider in particular a situation in which
G. Grimmett +8 more
core +1 more source
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
KIDS COUNT Indicator Brief: Reducing Infant Mortality [PDF]
Examines U.S. infant mortality trends by race/ethnicity and among industrialized nations. Outlines strategies to improve women's health, ensure timely prenatal care, address racial/ethnic disparities, and continue prevention efforts past the first ...
Barbara Shore, Rima Shore
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source

