Results 141 to 150 of about 627,123 (359)
Spontaneous traveling waves naturally emerge from horizontal fiber time delays and travel through locally asynchronous-irregular states [PDF]
, 2020 Zachary W. Davis +6 more
openalex +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Valuation of uncertainty in travel time and arrival time - some findings from a choice experiment [PDF]
We are developing a dynamic modeling framework in which we can evaluate the effects of different road pricing measures on individual choice behavior as well as on a network level.
Michiel Bliemer, Dirk Van Amelsfort
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Quantum mechanical model of a time travel paradox
, 2014 The retrocausality inherent in the retrodictive description of a quantum optical device called the quantum scissors allows this device to be used as a non-deterministic time machine.
Pegg, David
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Test of the relation between travel and activities times : different representations of a demand derived from activity participation [PDF]
The paper tests linear and non-linear specifications of the relationship between travel times and activity times, in 4 four French and three Swiss cities, observed at two different periods. First, following Kitamura et al.
Joly, I.
core
Roadway System Assessment Using Bluetooth-Based Automatic Vehicle Identification Travel Time Data
, 2012 This monograph is an exposition of several practice-ready methodologies for automatic vehicle identification (AVI) data collection systems. This includes considerations in the physical setup of the collection system as well as the interpretation of the ...
Brennan, Thomas M. +4 more
core +1 more source