Results 121 to 130 of about 627,123 (359)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Variations in the rational use of time – The travel pulse of commutes between home and job [PDF]

open access: yes
Ian Cullen and his research colleagues long ago suggested that people form habits in daily life that suboptimize behavior in view of constraints. Such rational suboptimization is posited here to apply to trips between home and work and to vary by time of
William Michelson
core  

The Art and Craft of Train Travel. [PDF]

open access: yes, 2008
Current theories concerning the social and material construction of time and space have little to say concerning the specific things and people involved.
Watts, Laura
core  

Beaming Bodies: A Neo-Lockean Account of Material Persistence

open access: yesPhilosophies
Conventional wisdom holds that human bodies do not and cannot persist through beaming: scanning and destruction of the body, followed by transmission of the scan information and replication of the body in another location.
Richard Mark Hanley
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Towards Developing a Travel Time Forecasting Model for Location-Based Services: a Review [PDF]

open access: yes
Travel time forecasting models have been studied intensively as a subject of Intelligent Transportation Systems (ITS), particularly in the topics of advanced traffic management systems (ATMS), advanced traveler information systems (ATIS), and commercial ...
Jinsoo You, Tschangho John Kim
core  

How far is too far?: Travel time ratios for activity participation in the Netherlands

open access: yes, 2009
It is widely believed that providing activity locations close to residential locations reduces the travel time of residents. However, it has not been clear how close to one another activity locations and residential locations should be.
Susilo, Yusak,   +2 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

On the Possibility of Time Travel [Elektronisk resurs]

open access: yes, 2010
Time travel can be defined as an experience and social practice in the present that evokes a past (or future) reality. In this paper I introduce popular time travel as a significant phenomenon of the Experience or Dream Society and the fast developing ...
Holtorf, Cornelius,
core  

Economic evaluation of road investment proposals: valuing travel time savings for freight. [PDF]

open access: yes, 2003
Faster more reliable freight movements make up a substantial proportion of the economic benefits generatedby road and transport investment. However techniques for assessing and valuing the freight component ofthis economic benefit have been rather ...
Tsolakis, Dimitris   +4 more
core  

Home - About - Disclaimer - Privacy