Results 91 to 100 of about 400,980 (279)
Advanced Science, EarlyView.A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong +13 more
wiley +1 more source
Final Report of the Netherlands State Commission on Euthanasia: An English Summary
, 1987 An unofficial summary is provided of the Final Report of the Netherlands State Commission on Euthanasia, submitted to the Minister of Welfare, Health and Cultural Affairs and the Minister of Justice on 19 Aug 1985.
core
Active Euthanasia in the Netherlands
, 1989 A Dutch bioethicist discusses the status of voluntary, active euthanasia as it is practiced currently in the Netherlands, and traces the medical, legal, and public policy developments in the issue from the early 1970s to the late 1980s.
de Wachter, Maurice A.M. +1 more
core +1 more source
Advanced Science, EarlyView.Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song +5 more
wiley +1 more source
Protection of genetic heritage in the era of cloning
Revista Brasileira de Hematologia e Hemoterapia, 2012 Research on human beings has expanded greatly due to progress and the evolution of society as well as customs. Not only the unceasing development of research on human beings, but also interference in the beginning and end of life with homologous and ...
Eudes Quintino de Oliveira Júnior +1 more
doaj
BMC Medical EthicsBackground In many Western countries, there is a growing tendency to seek control over death and dying. This leads to a practice in which people anticipate their hypothetical future by a timely explication of their end-of-life choices, such as do-not ...
Marte Fleur Antonides +3 more
doaj +1 more source
Advanced Science, EarlyView.IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou +11 more
wiley +1 more source
A Case Against Dutch Euthanasia
, 1989 The growing acceptance of voluntary active euthanasia by the Dutch is examined in relation to the plastic cards requesting active euthanasia carried by many people in The Netherlands, public opinion polls, and support by leading medical figures of the ...
Fenigsen, Richard
core +1 more source
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Euthanasia Across the North Sea
, 1988 The United Kingdom and the Netherlands are separated by a narrow stretch of sea but in terms of an understanding of euthanasia they seem to be light years apart. An attempt to bridge the information gap seems in order.
Borst-Eilers, Els +2 more
core +1 more source