Results 191 to 200 of about 3,237,112 (331)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Spontaneous Oscillatory Activity in Episodic Timing: An EEG Replication Study and Its Limitations. [PDF]

eNeuro
Bordas R, van Wassenhove V.
europepmc   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A behavioral integration mechanism underlies action timing. [PDF]

Sci Adv
Strassmann P, Cai X, Zhang B, Howard CD, Cook J, Jin X.   +5 more
europepmc   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Robust Timing Constraints for Granitic Magmatism and Hydrothermal Mineralization in the Tieshanlong W‐Sn Ore Field, Eastern Nanling Range, South China [PDF]

Wei Li, Juxing Tang, Na Guo, Xinghai Lang, Shiwei Song, Zhang Wu, Linlin Peng, Xiang Fang, Binfeng Chen, Dunmei Lian, Jie Lü   +10 more
openalex   +1 more source

Glia Regulate the Timing of Photoreceptor Differentiation in the Drosophila Visual System. [PDF]

Glia
Ren Q, Chang WT, Rao Y.
europepmc   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Time for Time: There’s No Time, We Have Time

Teksty Drugie
A short film online showing an encounter between an Indonesian bulldozer operator and two natives of an indigenous tribe on the island of Halmahera initiates a reflection on the clash and collision of the many times in which we live and reasons for the increasing importance of modern temporal consciousness.
openaire   +1 more source

Adherence to Surgical Antimicrobial Prophylaxis Guidelines and Improvement Efforts: A Single-Center, Pre- and Post-Intervention Comparison Study. [PDF]

Health Sci Rep
Yamamoto C, Nukui Y, Kosaka T, Aoto K, Kozen R, Hasegawa K, Ota C, Inoue Y, Taniguchi M, Hamashima R, Furukawa K, Kikuchi K, Nakanishi A, Teramukai S, Horii Y, Sawa T.   +15 more
europepmc   +1 more source