Results 51 to 60 of about 3,301,881 (350)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

The metabolic significance of peripheral tissue clocks

open access: yesCommunications Biology
The circadian clock is a transcriptional-translational feedback loop which oscillates in virtually all nucleated cells of the body. In the decades since its discovery, it has become evident that the molecular clockwork is inextricably linked to energy ...
A. Louise Hunter, David A. Bechtold
doaj   +1 more source

Transcriptional Signatures in Liver Reveal Metabolic Adaptations to Seasons in Migratory Blackheaded Buntings

open access: yesFrontiers in Physiology, 2018
The molecular underpinnings of metabolic adaptation to seasons are poorly understood in long- distance migrants. We measured changes in physiology and performed de novo sequencing of RNA extracted from liver samples collected at 4-h intervals over a ...
Devraj Singh   +3 more
doaj   +1 more source

Survey on positioning technology based on signal of opportunity from low earth orbit

open access: yesFrontiers in Physics
Positioning, Navigation, and Timing (PNT) services are essential for supporting various aspects of modern society. Fields such as communications, transportation, and military operations heavily rely on accurate and reliable PNT services, with this ...
Jiawei He   +9 more
doaj   +1 more source

Neurobiology of Posttraumatic Stress Disorder (PTSD) and its Frontostriatal Implications: a short review

open access: yesActualidades en Psicología, 2014
Throughout its evolutionary course, stress has remained as an adaptive response to stimuli that may jeopardize the integrity of an organism. Within this perspective, we can classify the stressors as psychological, physical or harmful to cardiovascular ...
Hugo Sánchez Castillo   +4 more
doaj   +1 more source

Sub-100-as timing jitter optical pulse trains from mode-locked Er-fiber lasers

open access: yes, 2011
We demonstrate sub-100-attosecond timing jitter optical pulse trains generated from free-running, 77.6-MHz repetition-rate, mode-locked Er-fiber lasers.
Chang Hee Nam   +17 more
core   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait   +23 more
wiley   +1 more source

A Comparison of Timing of Core Muscles between ACL Reconstructed and Healthy Athletes While Landing [PDF]

open access: yesSport Sciences and Health Research, 2016
Altered feed-forward mechanism of the motor control system can be one of the main reasons causing anterior cruciate ligament (ACL) sprain. The aim of this study was to examine the core muscles activation patterns in patients with ACL reconstruction (ACLR)
Kamal Rezaiee   +2 more
doaj   +1 more source

Detecting circumbinary planets using eclipse timing of binary stars - numerical simulations [PDF]

open access: yes, 2010
The presence of a body in an orbit around a close eclipsing binary star manifests itself through the light time effect influencing the observed times of eclipses as the close binary and the circumbinary companion both move around the common centre of ...
Alonso   +19 more
core   +1 more source

Time for Timed Monitorability

open access: yesCoRR
Monitoring is an important part of the verification toolbox, in particular in situations where exhaustive verification using, e.g., model-checking is infeasible. The goal of online monitoring is to determine the satisfaction or violation of a specification during runtime, i.e., based on finite execution prefixes.
Thomas Møller Grosen   +3 more
openaire   +3 more sources

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