Results 101 to 110 of about 19,573 (307)
Optimizing timing performance of CdTe detectors for PET
, 2017 Despite several attractive properties, the poor timing performance of compound semiconductor detectors such as CdTe and CdZnTe has hindered their use in commercial PET imaging systems.
Nakhostin, Mohammad, M Nakhostin
core +2 more sources
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Timing response characterization of MALTA monolithic pixel detectors
The MALTA monolithic active pixel detector has been developed to meet the stringent demands of future high-energy physics experiments. To assess its capabilities, we performed fast-timing studies to define a figure of merit for this family of detectors ...
Vazquez Nunez, M +22 more
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Upgrades for the Precision Proton Spectrometer at the LHC: Precision Timing and Tracking Detectors
, 2016 The CMS-TOTEM Precision Proton Spectrometer (CT-PPS) is an approved project to add tracking and timing information at approximately $\pm$210~m from the interaction point around the CMS detector.
Gallinaro, Michele, Michele Gallinaro
core +1 more source
EPJ Web of Conferences, 2016 The time-of-flight (TOF) mass spectrometry (MS), a high-resolution magnetic spectrometer equipped with a fast particle tracking system, is well recognized by its ability in weighing the most exotic nuclei.
Sun Bao-Hua +10 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Deep Diffused Avalanche Photodiodes for Charged Particles Timing
, 2019 The upgrades of ATLAS and CMS for the High Luminosity LHC (HL-LHC) highlighted physics objects timing as a tool to resolve primary interactions within a bunch crossing. Since the expected pile-up is around 200, with an r.m.s.
McClish, M. +31 more
core +1 more source