Results 61 to 70 of about 273,908 (268)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The Astronomical JournalBlue large-amplitude pulsators (BLAPs), a recently classified type of variable stars, are evolved objects likely formed through interactions between stars in a binary system.
Seung-Lee Kim +8 more
doaj +1 more source
On a Family of Variational Time Discretization Methods
, 2022 We consider a family of variational time discretizations that generalizes discontinuous Galerkin (dG) and continuous Galerkin-Petrov (cGP) methods. In addition to variational conditions the methods also contain collocation conditions in the time mesh points.
openaire +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
A Search for Subdwarf B Binaries Using Pulsation Timing from TESS
The Astronomical JournalHot subdwarf B (sdB) stars are post-main-sequence stars of high temperature and gravity. Approximately 30% of sdBs exhibit stable pressure and/or gravity-mode pulsations, which can be used via the timing method to test for companion stars and determine ...
Tomomi Otani +5 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Orbit Refinement of WASP-18 b and Evidence Against the Existence of WASP-18 c
The Astronomical JournalWe present an updated transit ephemeris for the exoplanet WASP-18 b and critically examine the existence of a proposed second planet, WASP-18 c. Using 205 transit light curves from the Transiting Exoplanet Survey Satellite, CHEOPS, Exoplanet Watch ...
Avinash S. Nediyedath +3 more
doaj +1 more source
Retirement timing and grandparenthood: A population-based study on Sweden
Demographic Research, 2017 Objective: This study addresses the importance of grandparenthood in relation to retirement timing in Sweden. It extends previous research by assessing a number of grandparental characteristics, such as being a grandparent, a grandparent's age and gender,
Linda Kridahl
doaj +1 more source