The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity [PDF]
European Journal of Medical Research, 2023 Background Inflammation, oxidative stress and an imbalance between proteases and protease inhibitors are recognized pathophysiological features of chronic obstructive pulmonary disease (COPD).
Sanja Dimic-Janjic +12 more
doaj +6 more sources
TIMP-1 Modulation Correlates with KRAS Dependency and EMT Induction in NSCLC [PDF]
CellsKirsten rat sarcoma viral oncogene homolog (KRAS) is one of the most frequently mutated genes in human cancer, including non-small cell lung carcinoma (NSCLC). Sustained expression of KRAS is required for survival in KRAS-dependent tumors.
Ilamathi M-Thirusenthilarasan +8 more
doaj +2 more sources
Estrogen‐dependent gene regulation: Molecular basis of TIMP‐1 as a sex‐specific biomarker for acute lung injury [PDF]
Physiological ReportsIncreased circulating tissue inhibitor of metalloproteinases‐1 (TIMP‐1) levels have been observed in patients with acute lung injury (ALI). However, the sex‐specific regulation of TIMP‐1 and the underlying molecular mechanisms have not been well ...
Sultan Almuntashiri +14 more
doaj +2 more sources
Investigating The variations in The expression level of CEA and TIMP-1 markers in Human Colorectal Carcinoma in Egyptian Patient [PDF]
Minia Journal of Medical Research, 2020 Background/Aims: In this current study, Our aim is studying verification and confirmation of the use of two markers of colorectal cancer in Egyptian patients to discover the disease and diagnose it early, because the deaths associated with it are ...
Shereen Gaber +3 more
doaj +1 more source
Natural haemozoin induces expression and release of human monocyte tissue inhibitor of metalloproteinase-1. [PDF]
PLoS ONE, 2013 Recently matrix metalloproteinase-9 (MMP-9) and its endogenous inhibitor (tissue inhibitor of metalloproteinase-1, TIMP-1) have been implicated in complicated malaria. In vivo, mice with cerebral malaria (CM) display high levels of both MMP-9 and TIMP-1,
Manuela Polimeni +6 more
doaj +1 more source
Comparative studies of TIMP-1 immunohistochemistry, TIMP-1 FISH analysis and plasma TIMP-1 in glioblastoma patients [PDF]
Journal of Neuro-Oncology, 2016 Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been associated with poor prognosis and resistance towards chemotherapy in several cancer forms. In a previous study we found an association between a low TIMP-1 tumor immunoreactivity and increased survival for glioblastoma patients, when compared to moderate and high TIMP-1 tumor immunoreactivity.
Aaberg-Jessen, Charlotte +7 more
openaire +5 more sources
Levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 are related to cardiopulmonary injury in fetal inflammatory response syndrome [PDF]
Clinics, 2020 OBJECTIVES: To evaluate the diagnostic value of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and the MMP-9/TIMP-1 ratio in fetal inflammatory response syndrome (FIRS), and determine a possible association with the
Yiwei Yan +6 more
doaj +1 more source
Zaporožskij Medicinskij Žurnal, 2020 Aim – to study the features of immunohistochemical expression of MMP-9, TIMP-1, MMP/TIMP ratio in the cerebral cortex in diabetes mellitus type 2. Materials and methods.
V. O. Shavrin , Yu. M. Avramenko
doaj +1 more source
Cells, 2023 Triple-negative breast cancer (TNBC) is among the most aggressive breast cancer subtypes. Despite being initially responsive to chemotherapy, patients develop drug-resistant and metastatic tumors.
Lisa Agnello +7 more
doaj +1 more source
The Mechanism of Inhibition of Collagenase by TIMP-1 [PDF]
Journal of Biological Chemistry, 1996 Tissue inhibitor of metalloproteinase-I (TIMP-1) is a slow, tight-binding inhibitor of fibroblast-type collagenase. Time-course data from inhibition experiments were analyzed by graphic analysis, by nonlinear regression of the analytic integrals of the rate equations and by nonlinear regression with numeric integration of the rate equations.
K B, Taylor +4 more
openaire +2 more sources