Results 111 to 120 of about 141,946 (275)

Fluorescence Lifetime Imaging Microscopy (FLIM) Data Analysis with TIMP [PDF]

Fluorescence Lifetime Imaging Microscopy (FLIM) allows fluorescence lifetime images of biological objects to be collected at 250 nm spatial resolution and at (sub-)nanosecond temporal resolution.
Vladimir V. Apanasovich, Ivo H. M. van Stokkum, Antonie J. W. G. Visser, Jan Willem Borst, Katharine M. Mullen, Sergey Laptenok   +5 more
core  

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Corticosteroids, rifampicin and LMWH impact plasma aMMP-8 and TIMP-1 and aMMP-8/TIMP-1 molar ratio in methicillin-sensitive Staphylococcus aureus bacteremia

International Journal of Infectious Diseases
Objectives: Matrix metalloproteinase-8 (MMP-8) and tissue inhibitor of metalloproteinases-1 (TIMP-1) predict outcomes in Staphylococcus aureus bacteremia (SAB).
Erik Forsblom, Asko Järvinen, Marjo Kivelä-Rajamäki, Eeva Ruotsalainen, Taina Tervahartiala, Timo Sorsa   +5 more
doaj   +1 more source

Elevated systemic levels of the matrix metalloproteinase inhibitor TIMP-1 correlate with clinical markers of cachexia in patients with chronic pancreatitis and pancreatic cancer

BMC Cancer, 2018
Background Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a candidate diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma (PDAC). Here, we determined the possible association of systemic TIMP-1 levels with cachexia and jaundice,
Olga Prokopchuk, Barbara Grünwald, Ulrich Nitsche, Carsten Jäger, Oleksii L. Prokopchuk, Elaine C. Schubert, Helmut Friess, Marc E. Martignoni, Achim Krüger   +8 more
doaj   +1 more source

The Landscape of Biomarkers in ICU-Associated AKI: From Protein Markers to Cell-Free Nucleic Acids. [PDF]

J Clin Lab Anal
Acute kidney injury (AKI) in critically ill patients—particularly in sepsis—often develops early and is missed by creatinine/urine output–based criteria, delaying risk stratification and timely intervention. This review synthesizes current evidence on established and emerging AKI biomarkers (e.g., NGAL, KIM‐1, [TIMP‐2]·[IGFBP7]) alongside circulating ...
Zhu Q, Yang F, Zheng H, Guo X, Chen Z, Chen L, Wang D, Wang J, Wang X, Huang Z, Ji Z.   +10 more
europepmc   +2 more sources

Soft‐Tissue Integration of Dental Implants: Formation, Maintenance, and Relevance for Peri‐Implant Health

Journal of Periodontal Research, EarlyView.
Sixty years after the introduction of dental implants, it is clear that soft‐tissue integration is as essential as osseointegration. This review outlines how peri‐implant soft tissues develop, protect, and sometimes fail, revealing key knowledge gaps and new opportunities to improve long‐term implant stability.
Fabiana Aellos, Axelle Clavelier, Bo Liu, Alison Wan, Giovanni E. Salvi, Mario Romandini, Jill A. Helms   +6 more
wiley   +1 more source

Diagnostic Accuracy Studies: Sensitivity, Specificity, and Beyond

Journal of Periodontal Research, EarlyView.
This methodological article covers key diagnostic accuracy measures, common pitfalls in diagnostic accuracy studies, and how evidence should progress from diagnostic accuracy to clinical effectiveness, with examples from various fields. ABSTRACT Diagnostic tests are central to medical care, and their evaluation remains methodologically challenging ...
Nancy Vegas, Lisa Friedlander, Jérémie F. Cohen   +2 more
wiley   +1 more source

Diagnostic Biomarkers of Periodontitis and Peri‐Implantitis: The Past, the Present, the Future

Journal of Periodontal Research, EarlyView.
Diagnostic biomarkers of periodontitis and peri‐implantititis from the past, through the present, and into the future. ABSTRACT In this narrative review we present our perspective on the past, present and future of periodontal and peri‐implantitis diagnostic biomarkers.
Denis F. Kinane, Başak Bıyıkoğlu
wiley   +1 more source

Relationship of MMP-14 and TIMP-3 Expression with Macrophage Activation and Human Atherosclerotic Plaque Vulnerability

Mediators of Inflammation, 2014
Matrix metalloproteinase-14 (MMP-14) promotes vulnerable plaque morphology in mice, whereas tissue inhibitor of metalloproteinases-3 (TIMP-3) overexpression is protective. MMP-14hi  TIMP-3lo rabbit foam cells are more invasive and more prone to apoptosis
Jason L. Johnson, Nicholas P. Jenkins, Wei-Chun Huang, Karina Di Gregoli, Graciela B. Sala-Newby, Vincent P. W. Scholtes, Frans L. Moll, Gerard Pasterkamp, Andrew C. Newby   +8 more
doaj   +1 more source

Smart Coatings Integrating Antimicrobial and Tissue‐Remodeling Functions for Implant Interfaces

Journal of Periodontal Research, EarlyView.
Schematic illustration of a dental implant system showing inflammation around a non‐coated abutment (left) and a stimuli‐responsive coated abutment (right). Acidification associated with inflammation triggers degradation of the PMAA‐based coating, enabling controlled antibiotic release from the LbL system and combating bacterial infection.
Mariana Martins Guerreiro, Amanda Paino Santana, Daniela Moreira Cunha, Gabriel Mulinari‐Santos, Marlise Inêz Klein, Edilson Ervolino, Ludovica Parisi, Martin Degen, Maria Eduarda Fiorentino Ferreira de Andrade, Marta Maria Alves Pereira, Stefany Barbosa Alves da Cruz, Leonardo P. Faverani, Paula Aboud Barbugli, Rodolfo Debone Piazza, Vitória Marega Marchetti, Rodrigo Isaias Lopes Pereira, Rafael Scaf de Molon, Anton Sculean, Erica Dorigatti de Avila   +18 more
wiley   +1 more source