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MMPs and TIMPs-An Historical Perspective
Molecular Biotechnology, 2002There are currently 25 known vertebrate matrix metalloproteinases (MMPs) and 4 tissue inhibitors of metalloproteinases (TIMPs). This article reviews these proteases from an historical perspective in terms of who discovered each protein, when the sequence was established, when action on protein substrates was demonstrated, and what names have been used.
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Immunohistochemistry of MMPs and TIMPs
2003Immunohistochemistry is a useful and powerful method to determine the cells responsible for the production of MMPs and TIMPs and localize them to the tissue areas where they are functioning. This chapter describes the detailed methods of the immunohistochemistry applied to human pathological tissues using commercially available monoclonal antibodies ...
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Equine TIMP‐1 and TIMP‐2: Identification, activity and cellular sources
Equine Veterinary Journal, 1998Summary Matrix metalloproteinases (MMPs) are the main enzymes involved in connective tissue turnover. Regulation of MMPs is achieved by controlling production, activation of the proenzymes together with the presence of inhibitors, such as, tissue inhibitors of metalloproteinases (TIMPS).
P D, Clegg, A R, Coughlan, S D, Carter
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2000
Abstract It is generally believed by those in the field that inhibition of proteolytic activity is the major function of the TIMPs. The growth effects are not widely recognized and have not received nearly the attention given to enzyme inhibition. The first point to be considered is whether all TlMPs inhibit all MMPs, and whether this is
J Frederick Woessner, Hideaki Nagase
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Abstract It is generally believed by those in the field that inhibition of proteolytic activity is the major function of the TIMPs. The growth effects are not widely recognized and have not received nearly the attention given to enzyme inhibition. The first point to be considered is whether all TlMPs inhibit all MMPs, and whether this is
J Frederick Woessner, Hideaki Nagase
openaire +1 more source
2000
Abstract Twenty-five amino acid alignments are presented at the end of the book. These are linked to a more complete description of each sequence presented in Table 4. For each item in Table 4 there is a number relating to the line number in the alignment.
J Frederick Woessner, Hideaki Nagase
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Abstract Twenty-five amino acid alignments are presented at the end of the book. These are linked to a more complete description of each sequence presented in Table 4. For each item in Table 4 there is a number relating to the line number in the alignment.
J Frederick Woessner, Hideaki Nagase
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Cut loose TIMP-1: an emerging cytokine in inflammation
Trends in Cell Biology, 2023Achim Kruger +2 more
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