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Sitagliptin Potentiates the Anticancer Activity of Doxorubicin Through ROS-Driven Apoptosis and MMP/TIMP Regulation in HeLa Cells. [PDF]
PharmaceuticsGüler AE, Tuncer MC, Özdemir İ.
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Targeting NF-kappa B/proinflammatory cytokines/ TGF-β/ TIMP-1 pathway by crocin enhances recovery from hepatic fibrosis in rats. [PDF]
Sci RepHassan MH, Salama SA, Ismail RS.
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Inhibition of stimulated bone resorption in vitro by TIMP-1 and TIMP-2
Biochimica Et Biophysica Acta - Molecular Cell Research, 1993Recombinant human TIMP-1 and TIMP-2 (tissue inhibitors of metalloproteinases) inhibited bone resorption induced by either parathyroid hormone or 1,25-dihydroxyvitamin D3 in cultured neonatal mouse calvariae. The inhibition was reversible, dose-dependent and complete at 1 microgram/ml inhibitor concentration. TIMP-2 was more potent than TIMP-1.
P A, Hill, J J, Reynolds, M C, Meikle
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Engineering of Selective TIMPs
Annals of the New York Academy of Sciences, 1999ABSTRACT: Differences in proteinase susceptibility between free TIMP‐1 and the TIMP‐1‐MMP‐3 complex and mutagenesis studies suggested that the residues around the disulfide bond between Cys1 and Cys70 in TIMP‐1 may interact with MMPs. The crystal structure of the complex between TIMP‐1 and the catalytic domain of MMP‐3 has revealed that the α‐amino ...
H, Nagase +7 more
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Critical Reviews in Oncology/Hematology, 2004
Tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of matrix metalloproteinases (MMPs) found in most tissues and body fluids. By inhibiting MMPs activities, they participate in tissue remodeling of the extracellular matrix (ECM). The balance between MMPs and TIMPs activities is involved in both normal and pathological events such as
Elise, Lambert +3 more
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Tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of matrix metalloproteinases (MMPs) found in most tissues and body fluids. By inhibiting MMPs activities, they participate in tissue remodeling of the extracellular matrix (ECM). The balance between MMPs and TIMPs activities is involved in both normal and pathological events such as
Elise, Lambert +3 more
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Clinicopathological correlations of TIMP‐1 and TIMP‐2 in Hodgkin's lymphoma
European Journal of Haematology, 2003Abstract:Objectives: The influence of matrix–tumour interactions in Hodgkin's lymphoma is poorly characterised, although a large part of the tumour often consists of reactive tissue. The aim of the present study was to assess the clinicopathological role of two main inhibitors of matrix metalloproteinases, TIMP‐1 and TIMP‐2, in Hodgkin's lymphoma ...
Heli, Pennanen +3 more
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TIMP-1 and TIMP-2 Levels in Vitreous and Subretinal Fluid
Japanese Journal of Ophthalmology, 1998To understand the role of tissue inhibitors of metalloproteinase-1 and -2 (TIMP-1 and TIMP-2) in intraocular diseases, levels of TIMP-1 and TIMP-2 were measured by enzyme immunoassay in 47 patients with various ocular diseases: in subretinal fluid of 7 patients with rhegmatogenous retinal detachment and in vitreous of 12 patients with proliferative ...
T, Matsuo +3 more
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Localization of TIMP-1, TIMP-2, TIMP-3, gelatinase A and gelatinase B in pathological human corneas
Current Eye Research, 1998Determine the tissue distribution patterns for tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2, TIMP-3), gelatinase A and gelatinase B in normal and pathologic corneas.Corneas were examined by immunohistochemistry, using antibodies to TIMP-1, TIMP-2, TIMP-3, gelatinase A or gelatinase B.In normal corneas, TIMP-1 antibody stained the epithelium ...
M C, Kenney +5 more
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MMPs and TIMPs-An Historical Perspective
Molecular Biotechnology, 2002There are currently 25 known vertebrate matrix metalloproteinases (MMPs) and 4 tissue inhibitors of metalloproteinases (TIMPs). This article reviews these proteases from an historical perspective in terms of who discovered each protein, when the sequence was established, when action on protein substrates was demonstrated, and what names have been used.
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