Results 61 to 70 of about 213,394 (265)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Prediction of long pile tip resistance based on CTNOA-SBL-MIC model

Yantu gongcheng xuebao
Machine learning (ML) has been widely used in pile foundation engineering modeling. However, predicting pile tip resistance of long piles remains a significant challenge, as pile tip resistance becomes substantial only when the pile is loaded and ...
WENG Kailiang1, 2, 3, , JIA Mincai1, 2 , SU Yan3
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Evaluation of the nanotube intrinsic resistance across the tip-carbon nanotube-metal substrate junction by Atomic Force Microscopy

Nanoscale Research Letters, 2011
Using an atomic force microscope (AFM) at a controlled contact force, we report the electrical signal response of multi-walled carbon nanotubes (MWCNTs) disposed on a golden thin film. In this investigation, we highlight first the theoretical calculation
Alamarguy David, Houzé Frédéric, Noël Sophie, Volz Sebastian, Dominiczak Maguy, Otubo Larissa, Bai Jinbo   +6 more
doaj  

Drag reduction design and experiments for the chisel-shaped shovel tip

Journal of Agricultural Engineering
To address the issue of high resistance encountered by traditional chisel-shaped shovel tips during tillage, this study drew inspiration from the micro V-shaped structures found in shark skin.
Longlong Wang, Changjiang Zheng, Mingke Li, Tongtong Mi, Songze Li, Xuemei Yi   +5 more
doaj   +1 more source

microRNA‐7‐5p and α‐Synuclein SAA Predict Parkinson's Disease Phenoconversion

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corroborate blood neuron‐derived extracellular vesicle (NDEV) alpha‐synuclein (αSyn), the CSF αSyn seed amplification assay (αSyn‐SAA), and blood microRNA‐7‐5p (miR‐7‐5p) as markers for Parkinson's disease (PD) phenoconversion and determine if combining these markers would help select subjects who would be more likely to phenoconvert.
Shayan Zadegan, Praveen Velammal, Kanmani Muthiah, Madhu Jatty, Christopher Adams   +4 more
wiley   +1 more source

Improvement of drawing stability and throughput in scanning probe lithography based on anti-wear probes

Nihon Kikai Gakkai ronbunshu, 2015
In this paper, we demonstrate the improvement in drawing stability and throughput of scanning probe lithography (SPL) based on anti-wear probes. In order to improve the stability of SPL, we conceive of a novel anti-wear probe to improve the wear ...
Yongfang LI, Yasushi TOMIZAWA, Masakazu SUGIYAMA, Hiroshi TOSHIYOSHI, Hiroyuki FUJITA   +4 more
doaj   +1 more source

Thermodynamic Pathways of Nonequilibrium Solidification in Wire‐Arc Additive Manufacturing Fe‐Based Multicomponent Alloy Structures

Advanced Engineering Materials, EarlyView.
Geometry‐driven thermal behavior in wire‐arc additive manufacturing (WAAM) influences microstructural evolution during nonequilibrium solidification of a chemically complex Fe–Cr–Nb–W–Mo–C nanocomposite system. By comparing different deposits configurations, distinct entropy–cooling rate correlations, segregation, and carbide evolution are revealed ...
Blanca Palacios, Anthony Gonzalez, Aleksander Aleman, Tyler Dolmetsch, Tanaji Paul, Arvind Agarwal   +5 more
wiley   +1 more source

Modeling and Analysis of a Piezoelectric Energy Harvester with Varying Cross-Sectional Area

Shock and Vibration, 2014
This paper reports on the modeling and on the experimental verification of electromechanically coupled beams with varying cross-sectional area for piezoelectric energy harvesting.
Maiara Rosa, Carlos De Marqui Junior
doaj   +1 more source

Towards Defect Phase Diagrams: From Research Data Management to Automated Workflows

Advanced Engineering Materials, EarlyView.
A research data management infrastructure is presented for the systematic integration of heterogeneous experimental and simulation data required for defect phase diagrams. The approach combines openBIS with a companion application for large‐object storage, automated metadata extraction, provenance tracking and federated data access, thereby supporting ...
Khalil Rejiba, Sang‐Hyeok Lee, Christina Gasper, Martina Freund, Sandra Korte‐Kerzel, Ulrich Kerzel   +5 more
wiley   +1 more source