Results 51 to 60 of about 213,394 (265)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Enhanced tensile properties and wear resistance of Tip/AZ31 composites prepared by hot-press sintering

Journal of Materials Research and Technology
For magnesium (Mg) matrix composites (MMCs), trade-off between strength and plasticity has long been an issue of puzzle. In this work, hot-press sintering and hot extrusion are used to prepare Ti particles (Tip) reinforced AZ31 (Tip/AZ31) composites. The
Junliu Ye, Jiaxin Wen, Jianbo Li, Huan Luo, Xianhua Chen, Tao Chen, Fusheng Pan   +6 more
doaj   +1 more source

Gating a Quantum Dot through the Sequential Removal of Single Electrons from a Nanoscale Floating Gate

PRX Quantum, 2023
We use the tip of an atomic force microscope (AFM) to charge floating metallic gates defined on the surface of a Si/SiGe heterostructure. The AFM tip serves as an ideal and movable cryogenic switch, allowing us to bias a floating gate to a specific ...
Artem O. Denisov, Gordian Fuchs, Seong W. Oh, Jason R. Petta   +3 more
doaj   +1 more source

Colonization of the tip of a thoracic catheter by Enterococcus faecalis resistant to vancomycin and linezolid [PDF]

Journal of Medical Microbiology, 2009
We report the isolation ofEnterococcus faecalisresistant to vancomycin and linezolid from the tip of a thoracic drainage catheter in an elderly patient. He was treated with vancomycin for a pleural empyema due to a meticillin-resistantStaphylococcus aureusbut never received linezolid.
CIAN F, LUZZATI, ROBERTO, DEIANA M. L, FERRANTELLI N, TONIN, ENRICO ANGELO, LAGATOLLA, CRISTINA, DOLZANI, LUCILLA   +6 more
openaire   +4 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Effects of the Tip Location on Single Piles Subjected to Surcharge and Axial Loads

The Scientific World Journal, 2013
When applying axial load on piles subjected to negative skin friction (NSF), the yielded NSF is gradually eliminated. The process is notably influenced by the tip location (Y) and still a lack of understanding.
Yaru Lv, Xuanming Ding, Dubo Wang
doaj   +1 more source

Estimating Bearing Capacity Factors and Cone Tip Resistance

Soils and Foundations, 2002
Bearing capacity factors, Nq and Nc, for deep foundations have been determined using the dimensionless cavity expansion factors, Fq and Fc. Both angle of friction, Φ, and rigidity index, Ir have significant effect on Nq and Nc. Nq - Φ curves for various values of Ir are prepared on the basis of analytically calculated value of Fq, Vesic's, λv, and ...
openaire   +2 more sources

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source