Results 121 to 130 of about 97,379 (308)

Pathophysiology of post-operative peritoneal adhesions [PDF]

, 2007
Post-operative peritoneal adhesions are fibrous bands of tissue joining together organs occurring in the majority of patients following laparotomy, leading to complications such as abdominal pain, infertility in women and intestinal obstruction.
Sulaiman, H
core  

Microneedle Optimization: Toward Enhancing Microneedle's Functionality and Breaking the Traditions

Small Structures
Microneedles hold remarkable potential for providing convenient and unique solutions for disease diagnosis and therapy. However, their integration into clinical practices has been slow, primarily due to the challenge of developing models that meet the ...
Elham Lori Zoudani, Nam‐Trung Nguyen, Navid Kashaninejad   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Validity of Instrument Assisted Soft Tissue Mobilization for Detecting Myofascial Adhesions through Secondary Diagnostic Ultrasound Analysis

, 2013
Context: many patients have pain and restricted motion due to myofascial adhesions. Clinicians use both manual and instrument assisted soft tissue mobilization (IASTM) techniques to treat myofascial adhesions. The main difference between manual therapies
Silbaugh, Kaitlyn
core  

Fibrin targeting microbubbles for the detection of nascent surgical adhesions

, 2023
Surgical adhesions are fibrous bands of scar tissue that form as a result of surgically induced damage to the peritoneum. Adhesions occur after 95% of abdominal surgeries and can cause severe complications.
McCarthy, Colleen
core  

An autologous blood-derived patch as an antiadhesive in a porcine uterine horn model

Heliyon
Background: Post-surgical adhesions, i.e., scar tissue inadvertently interlinking organs in the abdomen, is a common complication after surgery that can lead to infertility, small bowel obstruction and difficulties in subsequent surgeries. We explored an
Morten PR. Eskildsen, Otto Kalliokoski, Marie Boennelycke, Rasmus Lundquist, Annette Settnes, Ellen Loekkegaard   +5 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The Effect of Extensor Tendon Adhesions on Finger Motion

, 2019
Purpose: To quantify the amount and pattern of finger range of motion loss at the metacarpophalangeal (MCP), proximal interphalangeal (PIP), and distal interphalangeal (DIP) joints with a simulated extensor tendon adhesion at the level of the proximal ...
Clitherow, Harry DS, Smith, Belinda J, Clarke, Elizabeth C, Tonkin, Michael A, Singh, Harvinder P, Graham, David J   +5 more
core   +1 more source

Clinical Outcomes and Safety Profile of a Novel Hyaluronic Acid/Alginate Hydrogel in Hand and Microsurgical Procedures

Plastic and Reconstructive Surgery, Global Open
Background:. Soft tissue adhesions following hand and microsurgical procedures are frequent and debilitating complications, limiting tendon gliding, entrapping nerves, and impairing outcomes.
Connor Arquette, MD, Max Silverstein, MD, Mitchell K. Ng, MD, Bauback Safa, MD, MBA, Walter C. Lin, MD   +4 more
doaj   +1 more source