Results 41 to 50 of about 15,688 (284)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

From Adhesion to Detachment: Strategies to Design Tissue‐Adhesive Hydrogels

Advanced NanoBiomed Research
The use of tissue adhesives dates to 1940s when surgical glues were introduced for wound closure applications. However, current clinically used tissue adhesives (fibrin and cyanoacrylate glues) have limited adhesion strength and biocompatibility issues ...
Minh Hieu Ho, Quinn van Hilst, Xiaolin Cui, Yogambha Ramaswamy, Tim Woodfield, Jelena Rnjak-Kovacina, Steven G. Wise, Khoon S. Lim   +7 more
doaj   +1 more source

Evaluation of the Hemostatic Effect of an Innovative Tissue Adhesive during Extraction Therapy under Rivaroxaban in a Rodent Model

Journal of Functional Biomaterials, 2023
An increase in rivaroxaban therapies is associated with increased numbers of postoperative bleeding despite the use of hemostatic sponges, which are currently the gold standard treatment.
Marius Heitzer, Philipp Winnand, Anna Bock, Mark Ooms, Marie Sophie Katz, Kristian Kniha, Oliver Grottke, Frank Hölzle, Ali Modabber   +8 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Tissue adhesives for closure of surgical incisions.

, 2010
BACKGROUND: Sutures, staples and adhesive tapes are the traditional methods of wound closure, whilst tissue adhesives have entered clinical practice more recently.
Maarten van der Elst, Helen V Worthington, James Darcey, Paul Coulthard, Marco Esposito, Darcey, James, Oscar J F van Waes, Coulthard, Paul; id_orcid, van der Elst, Maarten, Worthington, Helen V.; id_orcid, van Waes, Oscar J F, Esposito, Marco   +11 more
core   +1 more source

Functionalized Multiarmed Polycaprolactones as Biocompatible Tissue Adhesives

, 2020
Existing tissue adhesives have a trade-off between adhesive strength and biocompatibility. Here, we report a series of biocompatible multiarmed polycaprolactones (PCL) as tissue adhesives that can be released from a hot glue gun and the length of each ...
Wei Zhang, Yueqin Zheng, Daniel S. Kohane (1286292), Manisha Mehta, Xiaoran Deng, Wei Zhang (405), Andong Liu (1553770), Alona Shagan, Sophie Lyon, Sophie Lyon (8649279), Andong Liu, Yueqin Zheng (4671847), Alona Shagan (4445110), Boaz Mizrahi, Tianjiao Ji, Xiaoran Deng (1631638), Boaz Mizrahi (1926049), Daniel S. Kohane, Tianjiao Ji (1396918), Manisha Mehta (5987126)   +19 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Tissue adhesives for closure of surgical incisions.

, 2014
BACKGROUND: Sutures (stitches), staples and adhesive tapes have been used for many years as methods of wound closure, but tissue adhesives have entered clinical practice more recently.
Riley, Philip; id_orcid, Worthington, Helen V; id_orcid, Worthington, H.V., Dumville, Jo; id_orcid, Dumville, Jo C; id_orcid, Darcey, James, Patel, Neil, Coulthard, Paul; id_orcid, van der Elst, Maarten, van Waes, Oscar J F, Esposito, Marco   +10 more
core   +1 more source