Results 41 to 50 of about 25,445 (221)

In Vivo Blockade of Murine ARTC2.2 During Cell Preparation Preserves the Vitality and Function of Liver Tissue-Resident Memory T Cells

open access: yesFrontiers in Immunology, 2018
On murine T cells, GPI-anchored ADP-ribosyltransferase 2.2 (ARTC2.2) ADP-ribosylates the P2X7 ion channel at arginine 125 in response to nicotinamide adenine dinucleotide (NAD+) released during cell preparation.
Björn Rissiek   +5 more
doaj   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

open access: yesFEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Left-Sided Inferior Vena Cava Encountered During Organ Retrieval Surgery: Report of Two Cases

open access: yesInternational Journal of Organ Transplantation Medicine, 2016
Left-sided inferior vena cava (IVC) is the second most common anatomical anomaly of the IVC after duplication. Herein, we present two cases of left-sided IVC, diagnosed during organ retrieval procedure.
Y Rajabnejad   +3 more
doaj  

The Risks in Presuming

open access: yesVoices in Bioethics, 2014
Organ transplantation brings up a myriad of bioethical issues, especially with regard to informed consent. In the US, an “opt-in” approach is practiced, in which patients’ organs will not be harvested unless they or their next-of-kin have provided ...
Louisa Howard
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

open access: yesFEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori   +8 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

One-Stage Transperineal Repair of Pan-Urethral Stricture With Dorsally Placed Buccal Mucosal Grafts: Results, Complications, and Surgical Technique

open access: yesUrology Journal, 2011
PURPOSE: To report the surgical details and results of one-stage transperinealurethroplasty using dorsal buccal mucosal graft (BMG) in treatment of panurethral stricture.MATERIALS AND METHODS: This cohort study was carried out on 17 men with pan-urethral
Kamyar Tavakkoli Tabassi   +2 more
doaj  

Effect of LIMA Harvesting Technique on Postoperative Drainage in Off-Pump CABG

open access: yesBrazilian Journal of Cardiovascular Surgery
Objective: We investigated the effects of pedicled and semiskeletonized left internal mammary artery (LIMA) harvesting techniques on postoperative drainage in patients subjected to off-pump CABG, ignoring other advantages or disadvantages of those ...
Mehmet Özülkü, Fatih Aygün
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Isolation and characterization of epithelial cells and fibroblasts from the human penile urethra

open access: yesFrontiers in Bioengineering and Biotechnology
IntroductionUrethral strictures and hypospadias are common urological conditions for which autologous reconstruction remains challenging. Tissue engineering offers a promising alternative, yet current strategies often rely on heterotopic cell sources ...
David Brownell   +9 more
doaj   +1 more source

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