Results 101 to 110 of about 36,410 (330)

Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

Advanced Science, EarlyView.
Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen, Yuqin Wu, Bofei Xu, Jiabei Hou, Yijing Li, Yuhan Hu, Yutuo Zhu, Wenqiao Zhang, Shuqi Feng, Huanting Jin, Yuchen Cheng, Yuanyuan Jin, Jianhong Zhou, Xingyi Li   +13 more
wiley   +1 more source

Indicadores de eficiência no processo de doação e transplante de órgãos: revisão sistemática da literatura

Revista Panamericana de Salud Pública
RESUMO Objetivo Verificar, por meio de revisão sistemática da literatura, os indicadores utilizados para acompanhar e controlar o processo de doação e transplante de órgãos e elaborar um painel para tipificação dos indicadores descritos na literatura ...
Marina Martins Siqueira, Claudia Affonso Araujo, Bartira de Aguiar Roza, Janine Schirmer   +3 more
doaj  

Donation of organs for transplant: ethical conflicts in the perception of professionals

O Mundo da Saúde, 2012
Organ transplants began to be successful in the Twentieth century, and became the last therapeutic resource in trying to preserve life. Thus, organ donation is essential to the promotion of transplants, although this process is traversed by moral and ...
Adriana Aparecida de Faria Lima
doaj  

Comparative analysis of family consent to tissue donation according to two different donation form structures

Einstein (São Paulo)
Objective To define donors’ profile of an Organ and Tissue Procurement Center and compare the family consent for tissue donation before and after modification of the Donation Term.Methods A descriptive, documentary and quantitative study performed in an ...
Manoela Gomes Grossi, Layse Beneli Prado, Geórgia Pereira Silveira Souza, Jaquelini Pereira dos Santos, Amanda Silva de Macêdo Bezerra, Cesar Augusto Guimarães Marcelino, Antônio Flávio Sanchez de Almeida, Andrea Cotait Ayoub   +7 more
doaj   +1 more source

CRISPR‐Cas9‐Loaded Theranostic Liposomes for Enhancing Radiosensitization of Prostate Cancer through POLD4 Gene Editing under Real‐Time MRI Monitoring

Advanced Science, EarlyView.
This study identifies POLD4 as a potential prostate cancer radiosensitization target through transcriptome sequencing. By encapsulating POLD4‐targeted CRISPR/Cas9 plasmids and USPIONs in cationic liposomes, an MRI‐monitored gene‐editing platform is established.
Xuhui Fan, Ruru Zhang, Linjun Yang, Shixiong Chen, Meijuan He, Yongqiang Wang, Linjie Huang, Jianfeng Zeng, Shuwang Wu, Mingyuan Gao, Han Wang   +10 more
wiley   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Protocol for Tissue Collection from Organ Procurement Organization v1

, 2020
Shin Lin, Yiing Lin
openalex   +1 more source

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Development of a Valid and Reliable Questionnaire to Identify Professional Opinion Regarding Organ Transplantation System

International Journal of Organ Transplantation Medicine, 2017
Background: Currently, the Nepalese law permits organ donation by an individual who falls into the category of a “close relative” of the recipient. There is a need for expansion of the live organ donor pool beside close relatives.
B Sah, A Ayer, BN Yadav, S Jha, SK Yadav
doaj  

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source