Results 21 to 30 of about 25,231 (199)

The brains of aged mice are characterized by altered tissue diffusion properties and cerebral microbleeds

Journal of Translational Medicine, 2020
Background Brain aging is a major risk factor in the progression of cognitive diseases including Alzheimer’s disease (AD) and vascular dementia. We investigated a mouse model of brain aging up to 24 months old (mo).
Erik N. Taylor, Nasi Huang, Jonathan Wisco, Yandan Wang, Kathleen G. Morgan, James A. Hamilton   +5 more
doaj   +1 more source

Aerobic exercise and metformin on intermuscular adipose tissue (IMAT): insights from multimodal MRI and histological changes in prediabetic rats

Diabetology & Metabolic Syndrome, 2023
Background Physical exercise is the first-line intervention for prediabetes, and metformin is the most widely used oral insulin-sensitizing agent. Moreover, intermuscular adipose tissue (IMAT) directly affects insulin resistance by helping maintain ...
Fuyao Yu, Chuan Xing, Yiping Fan, Yanping Liu, Peng Su, Qiuhua Yang, Yanbin Dong, Yang Hou, Shinong Pan   +8 more
doaj   +1 more source

The effects on type 2 diabetes mellitus mouse femoral bone achieved by anti-osteoporosis exercise interventions

Frontiers in Endocrinology, 2022
PurposeExercise therapy and key regulators of bone quality exert anti-hyperglycemic effects on type 2 diabetes mellitus (T2DM) mice. A number of programs have been reported to have an effect on bone disease in T2DM. Major unanswered questions concern the
Miao Zhang, Yuexuan Li, Lifei Liu, Lifei Liu, Mei Huang, Miao Wang, Jun Zou   +6 more
doaj   +1 more source

Scattered and Fluorescent Photon Track Reconstruction in a Biological Tissue

International Journal of Photoenergy, 2014
Appropriate analysis of biological tissue deep regions is important for tumor targeting. This paper is concentrated on photons’ paths analysis in such biotissue as brain, because optical probing depth of fluorescent and excitation radiation differs.
Maria N. Kholodtsova, Pavel V. Grachev, Tatiana A. Savelieva, Nina A. Kalyagina, Walter Blondel, Viktor B. Loschenov   +5 more
doaj   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Brain tissue pulsatility is related to clinical features of Parkinson's disease

NeuroImage: Clinical, 2018
Introduction: This study investigated whether brain tissue pulsatility is associated with features of disease severity in Parkinson's disease (PD). Methods: Data were extracted from the Parkinson's Progression Markers Initiative among 81 adults with PD ...
Zahra Shirzadi, Andrew D. Robertson, Arron W. Metcalfe, Sarah Duff-Canning, Connie Marras, Anthony E. Lang, Mario Masellis, Bradley J. MacIntosh   +7 more
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Microstructure of the human metastatic vertebral body

Frontiers in Endocrinology
IntroductionBone spinal metastases disrupt the bone homeostasis, inducing a local imbalance in the bone formation and/or resorption, with consequent loss of the structural optimisation of the vertebrae and increase of the risk of fracture.
Giulia Cavazzoni, Giulia Cavazzoni, Giulia Cavazzoni, Enrico Dall’Ara, Enrico Dall’Ara, Marco Palanca, Marco Palanca, Marco Palanca   +7 more
doaj   +1 more source

Tract profiles of white matter properties: automating fiber-tract quantification. [PDF]

PLoS ONE, 2012
Tractography based on diffusion weighted imaging (DWI) data is a method for identifying the major white matter fascicles (tracts) in the living human brain.
Jason D Yeatman, Robert F Dougherty, Nathaniel J Myall, Brian A Wandell, Heidi M Feldman   +4 more
doaj   +1 more source