Results 111 to 120 of about 39,471 (296)

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Termites of the Genus Cryptotermes Banks (Isoptera: Kalotermitidae) from the West Indies

, 1999
A taxonomic revision of the genus Cryptotermes occurring in the West Indies is given based on recent collections from the Greater Antilles, Lesser Antilles, and the Bahamas.
Krecek, Jan, Scheffrahn, Rodolf H.
core  

The development and deployment of Common Data Elements for tissue banks for translational research in cancer – An emerging standard based approach for the Mesothelioma Virtual Tissue Bank-3

, 2011
Ssociation of Directors of Anatomic and Surgical Pathology.Copyright information:Taken from "The development and deployment of Common Data Elements for tissue banks for translational research in cancer – An emerging standard based approach for the ...
Andrew K Pople (91017), Nancy B Whelan (91021), Anil V Parwani (32437), Harvey I Pass (91024), Erin Milliken (91019), Amita T Mistry (91015), Sharon B Winters (78586), Jonathan Melamed (2862), Waqas Amin (91016), Michael J Becich (2867), Emanuela Taioli (91023), Sambit K Mohanty (78581), Linda Schmandt (91018), Rajiv Dhir (2866), Paula Kim (91020), Ghada Farhat (91022)   +15 more
core   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Optical Coherence Tomography Imaging of Tissue Engineered Skin Cultured Under Perfusion Conditions [PDF]

, 2013
Tissue engineered (TE) human skin constructs are useful for the investigation of disease pathologies and for exploring the potencies and side effects of medicines and cosmetics.
Robertson, Caroline
core  

The development and deployment of Common Data Elements for tissue banks for translational research in cancer – An emerging standard based approach for the Mesothelioma Virtual Tissue Bank-1

, 2011
Tionary.Copyright information:Taken from "The development and deployment of Common Data Elements for tissue banks for translational research in cancer – An emerging standard based approach for the Mesothelioma Virtual Tissue Bank"http://www.biomedcentral.
Andrew K Pople (91017), Nancy B Whelan (91021), Anil V Parwani (32437), Harvey I Pass (91024), Erin Milliken (91019), Amita T Mistry (91015), Sharon B Winters (78586), Jonathan Melamed (2862), Waqas Amin (91016), Michael J Becich (2867), Emanuela Taioli (91023), Sambit K Mohanty (78581), Linda Schmandt (91018), Rajiv Dhir (2866), Paula Kim (91020), Ghada Farhat (91022)   +15 more
core   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

Comparison of histological procedures and antigenicity of human post-mortem brains fixed with solutions used in gross anatomy laboratories

Frontiers in Neuroanatomy
BackgroundBrain banks provide small tissue samples to researchers, while gross anatomy laboratories could provide larger samples, including complete brains to neuroscientists.
Eve-Marie Frigon, Amy Gérin-Lajoie, Mahsa Dadar, Denis Boire, Josefina Maranzano, Josefina Maranzano   +5 more
doaj   +1 more source