Results 151 to 160 of about 1,922,235 (275)

White and Clearing: New Optical Tissue Clearing Method

Abstract Optical tissue clearing techniques can render large-scale tissue samples and whole organs transparent to apply cell-resolution 3D imaging techniques, revolutionizing the fields of biological research and pathological diagnosis, and providing never-before seen structural information. There are
Vicente Llorente, Elena Fernández-Cortés, Daniel Sanderson, Julia Salazar, Jorge Ripoll, Manuel Desco, María Victoria Gómez-Gaviro   +6 more
openaire   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Immunolabeling and Tissue Clearing for Calcified Tissues v1

High-resolution 3D imaging is an important strategy for visualising and analysing complex skeletal tissue architecture and the bone marrow microenvironment1–5,11. However, multicolour immunolabeling and imaging of intact skeletal tissues remain technologically challenging.1,5,8,10,11 .
Zhangfan Ding, Hanyu Liu, Anjali Kusumbe
openaire   +1 more source

Current progress of labeling strategies in tissue clearing for large-scale biological visualization. [PDF]

Front Cell Dev Biol
Wang SW, Wang YQ, Deng JW, Yang SB, Wang FY, Wu J, Liu JG.   +6 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Technological advances in axonal regeneration and structural plasticity: optogenetics, single-cell omics, and tissue clearing. [PDF]

Front Cell Neurosci
Shu X, Zhang J, Qin Z.
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Stochastic Electrotransport device for tissue clearing application.

, 2018
One of the applications of the stochastic electrotransport device is tissues clearing. However, the price of the device is very expensive and not available for students and casual researchers.
Nguyen, Thong
core  

Optical Tissue Clearing and Small-Molecule Labeling of Paraffin-Embedded Breast Cancer and Axillary Lymph Node Human Tissue Samples. [PDF]

Bio Protoc
Schiffelers LDJ, Pisarović U, Bitorina A, Hildebrand S, Walravens B, van Nijnatten TJA, Kooreman LFS, Schueth A.   +7 more
europepmc   +1 more source