Results 181 to 190 of about 10,801,888 (291)

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

An accessible and open-source workflow for fabrication of custom PDMS culture chambers using 3D printing. [PDF]

MethodsX
Algarín A, Cabrera PL, Scagliusi SF, Daza P, Yúfera A, Martín D.   +5 more
europepmc   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

Human iPSC-Derived Brain Organoids: A Disease-Oriented Evaluation of Modeling Fidelity. [PDF]

Eur J Neurosci
Pokharel BR, Dickerson A, Shenoy SG, Ramasamy MS, Majumdar N, Cook PP, Akula SM.   +6 more
europepmc   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

Comparison of smear positivity from anterior and posterior (endothelial) corneal scrapings obtained per-operatively in patients undergoing therapeutic penetrating keratoplasty - A retrospective study. [PDF]

Indian J Ophthalmol
Buch PC, Shekhar S, Das S, Prakash N, Kumari D, Singh V, Prasad A, Gupta N, Mittal SK.   +8 more
europepmc   +1 more source

Water‐Soluble, Enzyme‐Degradable, and Hydrolyzable STAR Particles for Enhanced Drug Delivery to Skin

Advanced Healthcare Materials, EarlyView.
Biodegradable polymer STAR particles fabricated from water‐soluble, enzyme‐degradable, and hydrolyzable materials significantly enhance intradermal drug delivery. By replacing conventional non‐biodegradable materials, these STAR particles address environmental and safety concerns while expanding the potential of skin‐based drug delivery technologies ...
Aydin Sadeqi, Gülçin Arslan Azizoğlu, Mark R. Prausnitz   +2 more
wiley   +1 more source

Manufacturing, Cell Regulation, and Coculture Strategies for Vascularization and Neural Innervation of Skeletal Muscle Tissue. [PDF]

Adv Healthc Mater
Wang Z, He X, Zhong S, Liu J, Shi Z, Yin R, Liu Y.   +6 more
europepmc   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source